The
LYME disease, fetal transmission and fetal damage. /
La enfermedad de LYME, transmision
transplacentaria y daño fetal.
DATA-MEDICOS
DERMAGIC/EXPRESS 20-(212)
25 February 2.018 25 Febrero 2.018
ENGLISH EDITORIAL:
==================
Hello friends of the network DERMAGIC EXPRESS brings you today
another topic than what I have called the "SAGA" on the LYME
DISEASE, in this case the controversial issue of
TRANSPLACENTAL TRANSMISSION AND FETAL DAMAGE AND DEATH in
pregnant women and infected with the feared BORRELIA BURGDORFERI.
I have found numerous references; most claims that the
BORRELIA in pregnant women
with LYME DISEASE traverses the placenta and reaches the fetus
can cause multi organic damage, including the death of the same,
intrauterine or a few hours or days after birth. Other authors
say that this is false.
The CDC (Center of Control of Infectious Diseases) affirms that
if the pregnant woman with LYME does her treatment, the child
will be born healthy and recommends the use of the antibiotic
AMOXICILLIN, because DOXYCYCLINE can cause damage to the
developing fetus. The question here is what would happen if the
BORRELIA species is resistant to AMOXICILLIN? Or the antibiotic
to which BORRELIA is sensitive cannot be indicated because it
would harm the fetus?
BORRELIA BURGDORFERI was discovered in 1,982 by the
aforementioned Willy Burggdorfer, the causal agent of the
ERYTHEMA MIGRANS or LYME DISEASE, and only 1 years later in
1.983 the first study was described where it is suspected
that this ESPIROCHETE can cross the
placenta and infect
the fetus, study published by Shirts SR, Brown MS, and Bobitt
JR. under the name of "Listeriosis and borreliosis as causes of
antepartum fever". (8)
Later in the year 1,985 Schlesinger PA, Duray PH, Burke BA,
Steere AC, Stillman MT. They publish a paper called
"Maternal-fetal transmission of the spirochete of Lyme disease,
Borrelia burgdorferi" where they report a case of a woman
who developed LYME DISEASE and did not receive treatment with
antibiotics. The child was born at 35 weeks of pregnancy and
died of congenital heart disease the first week of life. The
autopsy revealed the
LYME ESPIROCHETE in the
SPLEEN, KIDNEYS AND BONE MARROW. (2)
Later the same WILLY BURGDORFER the discoverer and "father" of
the ESPIROCHETE BORRELIA, who along with Dr. Alan Mc Donald and
Jorge Benach PhD, published in the year 1.987 (31 years ago) a
work they called "stillbirth following maternal LYME DISEASE."
and I quote from the conclusions of these scientists: (24.)
"... Two cases of transplacental transmission of the BORRELIA
BURGDORFERI were found associated with fetal death and
congenital malformations, different anomalies were
detected in each case ..."
"... We recommend that pathologists study the tissues of
stillborn fetuses in search of BORRELIA BURGDORFERI especially
those with cardiac anomalies, and clinical doctors investigate
the exposure during the first trimester of pregnancy to BORRELIA
BURGDORFERI and in these cases determine if cardiac
organogenesis is complete by the end of the first trimester of
pregnancy”
"... We believe that there is enough evidence
to alert women living in endemic areas of LYME DISEASE
and doctors to recognize the early signs and symptoms of the
disease and to start treatment with PENICILLIN at the same dose
of SYPHILIS as used in pregnant women in the first trimester,
regardless of the results of the laboratory tests ... "
Another study that is worth noting is the one made by the
MEDLINE database updated for the year of July 2012, the last
revision of November 2012 of 88 journal articles from the PUBMED
database, which I summarize as follows:
Maternal-Fetal Transmission of Lyme Disease (RESULTS:
1.) Mothers with active Lyme Disease,Treated: 14.6% of the
pregnancies with sequelae,
2.) Untreated: 66.7% of the pregnancies with sequelae,
3.) Unknown as to treatment: 30.3% with sequelae.
4.) Specific adverse outcomes included: cardiac 22.7%,
neurologic 15.2%, orthopedic 12.1%, ophthalmic 4.5%,
genitourinary 10.6%, miscellaneous anomalies 12.1%, 2nd
trimester demise 12.1%. Highest rate of adverse outcome (72.7%)
in women with infection acquired prior to or during first
trimester.)
Now I will put a summary of the most frequent clinical
manifestations described in the studies of children born to
mothers with LYME disease, LYME positive
COMMON SIGNS AND SYMPTOMS IN LYME POSITIVE CHILDREN:
=====================================================
1.) LOW GRADE FEVER: 59% -60%
2.) FATIGUE AND LACK OF RESISTANCE: 72%
3.) NOCTURNAL SWEATING: 23%
4.) PALE, DARK CIRCLE UNDER THE EYES: 42%
5.) ABDOMINAL PAIN: 20-29%
6.) DIARRHEA OR CONSTIPATION: 32%
7.) NAUSEA: 23%
8.) CARDIAC ANOMALIES: 23%: PALPITATIONS, (PVC) HERAT MURMUR,
MITRAL VALVLE PROLAPSE
9.) ORTHOPEDIC DISORDERS: SENSITIVITY (55%), PAIN (69%) SPASMS
AND GENERALIZED MUSCLE PAIN (69%), RIGIDITY AND / OR DELAY OF
MOVEMENTS (23%).
10.) RESPIRATORY INFECTIONS OF THE SUPERIOR TRACT AND OTITIS:
40%
11.) ARTHRITIC DISORDERS AND PAINFUL JOINTS: 6% -50-%
12.) NEUROLOGICAL DISORDERS:
A- HEADACHES: 50%
B-) IRRITABILITY: 54%.
C-) BAD MEMORY: 39%
13.) DELAY IN DEVELOPMENT: 18%
14.) SEIZURE DISORDERS: 11%
15.) VERTIGO: 30%
16.) TIC DISORDERS: 14%
17.) INVOLUNTARY ATETOID MOVEMENTS: 9%.
18.) LEARNING DISORDERS AND HUMOR CHANGES: 80%
A-) COGNITIVE SPEAKING: 27%
B-) SPEACH DELAY: 21%
C-) READING-WRITING PROBLEMS: 19%
D.) PROBLEMS OF VOCAL ARTICULATION: 17%.
E-) PROBLEMS OF AUDITIVES / VISUAL PROCESSING: 13%
F-) WORD SELECTION PROBLEMS: 12%
G-) DYSLEXIA: 8%
19.) SUICIDAL THOUGHTS: 7%
20.) ANXIETY: 21%
21.) ANGER OR RAGE: 23%
22.) AGGRESSION OR VIOLENCE: 13%
23.) IRRITABILITY: 54% -80%
24.) EMOTIONAL DISORDERS: 13%
25.) DEPRESSION: 13%
26.) HYPERACTIVITY: 36%
27.) PHOTOPHOBIA: 40-43%
28.) GASTROESOPHAGEAL REFLUX WITH VOMIT AND COUGH: 40%
29.) SECONDARY ERUPTIONS: 23%
30.) OTHER ERUPTIONS: 45%
31.) CAVERNOUS HAEMANGIOMA: 30%
32.) OULAR PROBLEMS: POSTERIOR CATARACTS, MYOPIA, STIGMATISM,
CONJUNCTIVE ERYTHEMA (LYME EYES), OPTICAL NERVE ATROPHY AND / OR
UVEITIS: 30%
44.) FATIGUE AND LACK OF RESISTANCE: 72%
45.) SENSITIVITY OF SKIN AND NOISE (HYPERACUITY): 36-40%
46.) AUTISM.
There are numerous studies showing a clear EVIDENCE that
the BORRELIA BURGDORGFERI
in pregnant women is able to cross the placenta and infect
the fetus. I could get tired here of giving you the description
of each of them. But I will give you ALL the BIBLIOGRAPHIC
REFERENCES that I found from the year 1.983 until the year
2.017, first the ones I found and then a chronology of ALL of
them.
I close this issue which is HIGHLY DISCUSSED TODAY, with
a post by Angélica Johansson,
a great fighter against THIS PLAGUE that I found in my LINKEDIN
network about the future of the planet and the LYME DISEASE ...
I quote:
"..."1 million people are predicted to get infected with Lyme
disease in the USA in 2018. Given the same incidence rate of
Lyme disease in Europe as in the USA, then 2.4 million people
will get infected with Lyme disease in Europe in 2018. In the
USA by 2050, 55.7 million people (12% of the population) will
have been infected with Lyme disease. In Europe by 2050, 134.9
million people (17% of the population) will have been infected
with Lyme disease. Most of these infections will, unfortunately,
become chronic.
The estimated treatment cost for acute and chronic Lyme disease
for 2018 for the USA is somewhere between 4.8 billion USD and
9.6 billion USD and for Europe somewhere between 10.1 billion
EUR and 20.1 billion EUR. If governments do not finance IV
treatment with antibiotics for chronic Lyme disease, then the
estimated government cost for chronic Lyme disease for 2018 for
the USA is 10.1 billion USD and in Europe 20.1 billion EUR.
If governments in the USA and Europe want to minimize future
costs and maximize future revenues, then they should pay for IV
antibiotic treatment up to a year even if the estimated cure
rate is as low as 25%. The cost for governments of having
chronic Lyme patients sick in perpetuity is very large...."
But what you see every day is a fight between IDSA and ILADS,
CDC and others on the subject of whether it is a simple tick
bite and you take an antibiotic and you cure or that it is a
disease of difficult diagnosis and high cost of treatment.
Between believers and non-believers to summarize. The truth
is that it is spreading all over the world in leaps and bounds.
And if you have doubts that this ESPIROCHETE may or may not harm
the fetus of pregnant women, cause birth defects, and many other
consequences including, stillborn babies, read this
"MOUNTAIN" of references that I leave here.
CONCLUSION: BORRELIA
BURGDORFERI, not only transmitted by the tick bite, is
TRANSMITTED by sexual contact, fluids and can also
colonize the fetus of pregnant women if there is no
effective treatment able to eradicate it during the same. And it
is not exclusive to the Northern Hemisphere. The BORRELIA
is also in the Southern Hemisphere.
Greetings to all.
Dr. José Lapenta.
EDITORIAL ESPAÑOL:
==================
Hola amigos de la red DERMAGIC EXPRESS te trae hoy otro tema
más de lo que he llamado la "SAGA" sobre la ENFERMEDAD DE
LYME, en este caso el controversial tema de la
TRANSMISION TRANSPLACENTARIA, DAÑO FETAL Y MUERTE en las
mujeres embarazadas e infectadas con la temida BORRELIA
BURGDORFERI.
He encontrado numerosas referencias, la MAYORIA afirman que
la BORRELIA en las mujeres embarazadas con ENFERMEDAD DE
LYME atraviesa la placenta
y llega al feto pudiendo causar daño multi orgánico,
inclusive la muerte del mismo, intrauterino o pocas horas o
días luego de nacido. Otros autores dicen que esto es falso.
El CDC (Centro de Control de Enfermedades Infecciosas)
afirma que si la mujer embarazada con LYME si hace su
tratamiento, él niño nacerá sano y recomienda para ello el
uso del antibiótico AMOXICILINA, porque la DOXICICLINA
puede ocasionar daño al feto en desarrollo. La pregunta aquí
es que pasaría si la especie de BORRELIA es resistente a
AMOXIXILINA? o el antibiótico a la cual es sensible la
BORRELIA no se le puede indicar porque dañaría al feto?
La BORRELIA BURGDORFERI fue descubierta en 1.982 por el ya
mencionado Willy Burggdorfer, agente causal del ERITEMA
MIGRANS O ENFERMEDAD DE LYME, y apenas 1 año después en
1.983 se describe el primer estudio donde se sospecha que
esta ESPIROQUETA puede
atravesar la placenta e infectar al feto
estudio publicado por Shirts SR, Brown MS, y Bobitt
JR. bajo el nombre de "Listeriosis y borreliosis como
causas de fiebre anteparto". (8)
Posteriormente en el año 1.985 Schlesinger PA, Duray PH,
Burke BA, Steere AC, Stillman MT. Publican un trabajo
denominado "Transmisión materno-fetal de la espiroqueta
de la enfermedad de Lyme, Borrelia burgdorferi" donde
reportan un caso de una mujer que desarrollo la ENFERMEDAD
DE LYME y no recibió tratamiento con antibióticos. El niño
nació a las 35 semanas de embarazo y murió de enfermedad
congénita del corazón la primera semana de vida. La
autopsia revelo la ESPIROQUETA de
LYME en el BAZO, RIÑONES Y MEDULA OSEA. (2)
Posteriormente el mismo WILLY BURGDORFER el descubridor y
"padre" de la ESPIROQUETA BORRELIA, quien en junto con el
Dr. Alan Mc Donald y Jorge Benach PhD, publican en él año
1.987 (hace 31 años) un trabajo que denominaron" niños
nacidos muertos asociados a LYME DISEASE en embarazadas."
y cito textualmente parte de las conclusiones de estos
científicos: (24.)
".... A dos casos de transmisión transplacentaria de la
BORRELIA BURGDORFERI se les encontró asociación con
muerte fetal y malformaciones congénitas,
diferentes anomalías fueron detectadas en cada caso..."
"... Recomendamos a los patólogos estudiar los tejidos de
los fetos nacidos muertos en busca de BORRELIA
BURGDORFERI sobre todo aquellos con anomalías cardiacas. Y
los médicos clínicos investigar la exposición durante el
primer trimestre del embarazo a la BORRELIA BURGDORFERI y en
esto casos determinar si la organogénesis cardiaca esta
completa el final del primer trimestre del embarazo"
"...Nosotros creemos que existen suficientes evidencias
para alertar a las mujeres que
viven en aéreas endémicas DE ENFERMEDAD DE LYME y
a los médicos reconocer los signos y síntomas tempranos de
la enfermedad e instaurar tratamiento con PENICILINA a la
misma dosis de la SIFILIS que se usa en las embarazadas en
el primer trimestre, independientemente del resultado que
muestren los exámenes de laboratorio..."
Otro de los estudios que vale la pena destacar es el
realizado por la base de datos MEDLINE actualizado para él
año Julio 2.012, última revisión Noviembre 2.012 de 88
artículos de revistas de la base de datos PUBMED, el cual
resumo así"
Transmisión materno-fetal
de la enfermedad de Lyme (RESULTADOS:
1.) Madres con enfermedad de Lyme activa, tratada: 14.6%
de los embarazos con secuelas,
2.) No tratada: 66.7% de los embarazos con secuelas,
3.) Desconocida en cuanto al tratamiento: 30.3% con secuelas.
4.) Resultados adversos específicos incluidos: cardíaco
22.7%, neurológico 15.2%, ortopédico 12.1%, oftalmológico
4.5%, genitourinario 10.6%, anomalías misceláneas 12.1%,
desaparición del segundo trimestre 12.1%. Tasa más alta de
resultado
Ahora te colocare un resumen de las manifestaciones clínicas
mas frecuentes descritas en los estudios de niños con
nacidos de madres con enfermedad de LYME, LYME positivos
SIGNOS Y SINTOMAS MAS COMUNES EN NIÑOS LYME POSITIVOS:
=======================================================
1.) FIEBRE DE BAJO GRADO: 59%-60%
2.) FATIGA Y FALTA DE RESISTENCIA: 72%
3.) SUDOR NOCTURNAL: 23%
4.) PALIDEZ, OJERAS: 42%
5.) DOLOR ABDOMINAL: 20-29%
6.) DIARREA O ESTREÑIMIENTO: 32%
7.) NAUSEAS: 23%
8.) ANOMALIAS CARDIACAS: 23%: PALPITACIONES, (PVC) SOPLO
CARDICACO, PROLAPSO DE VALVULA MITRAL.
9.) TRASTORNOS ORTOPEDICOS: SENSIBILIDAD (55%), DOLOR (69%)
ESPASMOS Y DOLORES MUSCULARES GENERALIZADOS (69%), RIGIDEZ Y
/O RETRASO DE MOVIMIENTOS (23%).
10.) INFECCIONES RESPIRATORIAS DEL TRACTO SUPERIOR Y OTITIS:
40%
11.) TRASTORNOS ARTRITICOS Y ARTICULACIONES DOLOROSAS:
6%-50-%
12.) TRASTORNOS NEUROLOGICOS:
A- DOLORES DE CABEZA: 50%
B-) IRRITABILIDAD: 54%.
C-) MALA MEMORIA: 39%
13.) RETRASO EN EL DESARROLLO: 18%
14.) TRASTONOS CONVULSIVOS: 11%
15.) VERTIGO: 30%
16.) TIC NERVIOSO: 14%
17.) MOVIMIENTOS ATETOIDES INVOLUNTARIOS: 9%.
18.) TRASTORNOS DEL APRENDIZAJE Y CAMBIOS DE HUMOR: 80%
A-) HABLA COGNITIVA: 27%
B-) RETRASO: 21%
C-) PROBLEMAS DE LECTURA-ESCRITURA: 19%
D.) PROBLEMAS DE ARTICULACION VOCAL: 17%.
E-) PROBLEMAS DE PROCESAMIENTO AUDITIVO / VISUAL: 13%
F-) PROBLEMAS DE SELECCION DE PALABRAS: 12%
G-) DISLEXIA: 8%
19.) PENSAMIENTOS SUICIDAS: 7%
20.) ANSIEDAD: 21%
21.) IRA: 23%
22.) AGRESION O VIOLENCIA: 13%
23.) IRRITABILIDAD: 54%-80%
24.) LABILIDAD EMOCIONAL: 13%
25.) DEPRESION: 13%
26.) HIPERACTIVIDAD: 36%
27.) FOTOFOBIA: 40-43%
28.) REFLUJO GASTROESOFAGICO CON VOMITO Y TOS: 40%
29.) ERUPCIONES SECUNDARIAS: 23%
30.) OTRAS ERUPCIONES: 45%
31.) HEMANGIOMA CAVERNOSO 30%
32.) PROBLEMAS COULARES: CATARATAS POSTERIORES, MIOPIA,
STIGMATISMO, ERITEMA CONJUNTIVAL (OJOS DE LYME), ATROFIA DEL
NERVIO OPTICO Y / O UVEITIS: 30%
44.) FATIGA Y FALTA DE RESISTENCIA: 72%
45.) SENSIBILIDAD DE LA PIEL Y AL RUIDO: 40%
46.) AUTISMO.
Existen numerosos estudios donde se muestra una
clara EVIDENCIA que la BORRELIA BURGDORGFERI en las
embarazadas es capaz de atravesar
la placenta e infectar al feto.
Me podría cansar aquí de ponerte la descripción de
cada uno de ellos. Pero te pondré TODAS LAS REFERENCIAS
BIBLIOGRAFICAS que encontré desde el año 1.983 hasta el año
2.017, primero las que yo encontré y luego una cronología de
TODAS ellas.
Cierro este tema el cual es ALTAMENTE DISCUTIDO HOY DIA,
con un post de Angélica
Johansson gran luchadora contra ESTA PLAGA que
encontré en mi red de LINKEDIN sobre el futuro del planeta y
la ENFERMEDAD DE LYME....Cito textualmente:
"... Se predice que 1 millón de personas se infectarán con
la enfermedad de Lyme en los EE. UU. En 2018. Dada la misma
tasa de incidencia de la enfermedad de Lyme en Europa que en
los EE. UU., En 2018, 2.4 millones de personas se
contagiarán con la enfermedad de Lyme en EE. UU. Para 2050,
55.7 millones de personas (12% de la población) habrán sido
infectadas con la enfermedad de Lyme. En Europa para 2050,
134.9 millones de personas (17% de la población) habrán sido
infectadas con la enfermedad de Lyme. La mayoría de estas
infecciones, desafortunadamente, se volverán crónicas.
El costo estimado del tratamiento para la enfermedad de Lyme
aguda y crónica para 2018 en los EE. UU. Se encuentra entre
4.800 millones de dólares y 9.600 millones de dólares, y
para Europa en algún lugar entre 10.100 millones de euros y
20.100 millones de euros. Si los gobiernos no financian el
tratamiento IV con antibióticos para la enfermedad de Lyme
crónica, entonces el costo gubernamental estimado para la
enfermedad de Lyme crónica para 2018 en los Estados Unidos
es de 10,1 mil millones de dólares estadounidenses y en
Europa de 20,1 mil millones de euros.
Si los gobiernos de los EE. UU. Y Europa quieren minimizar
los costos futuros y maximizar los ingresos futuros,
entonces deben pagar el tratamiento antibiótico IV hasta un
año, incluso si la tasa de curación estimada es tan baja
como del 25%. El costo para los gobiernos de tener enfermos
crónicos de Lyme a perpetuidad es muy grande "...
Pero lo que tú ves a diario es una pelea entre IDSA E
ILADS, CDC y otros sobre el tema de que si es una simple
picadura de garrapata y te tomas un antibiótico y te curas o
que es una enfermedad de difícil diagnostico y alto costo de
tratamiento. Entre creedores y no creedores para resumir.
Lo cierto es que se está diseminando por todo el mundo a
pasos agigantados.
Y si tienes dudas de que esta
ESPIROQUETA puede o no dañar el feto de las
mujeres embarazadas, causar defectos congénitos, y muchas
otras secuelas inclusive, niños nacidos muertos, Léete esta
"MONTAÑA" de referencias que aquí te dejo.
CONCLUSION: LA BORRELIA BURGDORFERI, no solo se
transmite por la picadura de la garrapata, SE TRANSMITE por
contacto sexual, fluidos y además de ello puede
colonizar el feto de las mujeres embarazadas si no hay
un efectivo tratamiento capaza de erradicarla durante el
mismo. Y no es exclusiva del hemisferio Norte. La
BORRELIA también está en el hemisferio Sur.
Saludos a todos.
Dr. José Lapenta.
=========================================================
BIBLIOGRAPHICAL REFERENCES /
REFERENCIAS BIBLIOGRAFICAS
========================================================
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Aguero-Rosenfeld M, Beneck D, Coleman J, Schwartz I.
6.) Detection of Borrelia burgdorferi DNA in urine of
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Luksa V, Candussi G, Rizzi GM, Trevisan G.
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James M O’Brien 1. and 2 Odessa P Hamidi. Division of
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USA. Department of Obstetrics and Gynecology, Pennsylvania
College of Medicine, USA.
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fetal death..Amanda B Macdonald
Published .1986 in Zentralblatt fur Bakteriologie,
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Dittman. Sr, Sacred Heart Medical Center, Spokane, WA.
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Susan M. Cox. Department of Obstetrics and Gynecology,
University of Texas Southwaestern Medical Center, Dallas, TX
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Compiled Dec 6, 2017 – by JC and Sue Faber RN
www.lymehope.ca
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DATA-MEDICOS/DERMAGIC-EXPRESS No 20-(212) 25/02/2.018 DR. JOSE LAPENTA R.
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Maracay Estado Aragua Venezuela 2.018
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