Publications

Refereed Journal Articles

Abstracts

Review papers

• Kumar, B., Vijayakumar, M., Govindarajan, R., Pushpangadan, P. (2007) Ethnopharmacological approaches to wound healing—Exploring medicinal plants of India. Journal of Ethnopharmacology 114:103-113

• Govindarajan, R., Vijayakumar, M., Pushpangadan, P. (2005) Review: Antioxidant approach to disease management and the role of ‘Rasayana’ herbs of Ayurveda. J. Ethnopharmacol. 99(2):165-178.

• Puspangadan, P, Govindarajan R., Vijayakumar, M. (2005). Diabetes Mellitus and its traditional remedies using Indian medicinal plants. Ayush Tommorrow 1(2): 31-52.

• Vijakumar, M., Govindarajan, R., Singh, D. P., Rawat AKS. (2005) Review of some important plants with antioxidant and biological activities. PHCOG MAG 1(4): 129-135.

Papers Published

        2010

• Srivastava S, Govindarajan R, Rawat AKS (2010) Phytochemical and antioxidant studies of two Anogeissus species Proceedings Of The National Academy Of Sciences India Section B-Biological Sciences. 80: 72-80.

         2009

• Niranjan A, Barthwal J, Lehri A, Govindarajan R. (2009) Development and Validation of an HPLC-UV-MS-MS Method for Identification and Quantification of Polyphenols in Artemisia pallens L. Acta Chromatographica. 21(1): 105-116.

        2008

• Govindarajan, R., Singh, D.P., Rawat, A.K.S (2008) Validated RP-HPLC method for standardization of Ashokarishta. Chromatographia. 68: 873-876.
• Govindarajan, R., Singh, D.P., Rawat, A.K.S. (2008) Validated RP-HPLC method for separation and quantitation of polyphenolics and furocoumarins in herbal drugs. Journal of AOAC. 91(5): 1020-1024.
• Singh Meenakshi, Govindarajan Raghavan, Rawat Ajay Kumar Singh, and Khare  Prem B. (2008). Antimicrobial Flavonoid Rutin from Pteris Vittata L. Against Pathogenic Gastrointestinal Microflora. American Fern Journal 98(2):  98–103.  2.
• Nautiyal, C. S., Govindarajan, R., Lavania, M., Pushpangadan, P., (2008) Novel Mechanism of Modulating Natural Antioxidants in Functional Foods: Involvement of Plant Growth Promoting Rhizobacteria NRRL B-30488. Journal of Agriculture and Food Chemistry. 56(12): 4474-4481.
• Singh, D. P., Govindarajan, R., Rawat, AKS. (2008) High Performance Liquid chromatography as a tool for the chemical standardization of Triphala – an Ayurvedic formulation. Phytochemical Analysis. 19(2): 164-168.
• Govindarajan, R., Vijaykumar, M., Rao , Ch. V., Pushpangadan, P., Asare-Anane, H., Persaud, S., Jones, P. and Houghton, P.J. (2008) Antidiabetic activity of Croton klotschianus in rats and direct stimulation of insulin secretion in-vitro. Journal of Pharmacy and Pharmacology 60: 371-376.
• Singh, D. P., Govindarajan, R., Rawat, AKS. (2008) Comparison of different analytical HPLC columns for determination of furocoumarins in Heracleum candicans fruits. Journal of Liquid chromatography and Related technology. 31(3): 421-427

• Singh, D. P., Srivastava SK., Govindarajan, R., Rawat, AKS (2007) High Performance liquid chromatographic determination of bergenin in different Bergenia species. Acta Chromatographica 19: 246-252.

• Singh, A.P., Singh, D. P., Srivastava SK., Govindarajan, R., Rawat, AKS (2007) A validated quantitative HPTLC method for analysis of biomarkers in Ficus carica L. Journal of Planar Chromatography. 20(6): 437-441.

• Singh, D. P., Govindarajan, R., Rawat, AKS. (2007) Optimization of a High-Performance Liquid Chromatography Method for the Separation and Identification of Six different classes of phenolics. Journal of Chromatographic Science 45: 701-705.

• Govindarajan, R, Houghton, PJ, Asare-Anane, H, Persaud, S, Jones, P (2007) In vivo and in vitro evidence for anticliabetic activity of Desmodium gangeticum Planta Medica, 73 (9): 813-813.

• Annan, K, Houghton, PJ, Govindarajan, R (2007) In vitro and in vivo wound healing actions of Paullinia pinnata L. Planta Medica, 73 (9): 968-969 .

• Dickson, RA, Houghton, PJ, Govindarajan, R (2007) In-vitro and in-vivo wound healing properties of two plants from Ghana. Planta Medica, 73 (9): 969-969.

• R. Govindarajan, M. Vijayakumar, Ch. V. Rao, A. Shirwaikar, Santhosh Kumar, A. K. S. Rawat and P. Pushpangadan (2007) Anti-inflammatory and antioxidant activities of Desmodium gangeticum fractions in carrageenan induced inflamed rats Phytotherapy Research 21(10): 975-979.

• Govindarajan R, Singh, D.P., Singh, A. P., Pandey, M. M., Rawat, AKS (2007) A validated HPLC method for quantification and optimization of furocoumarins in different extracts of fruits of Heracleum candicans. Chromatographia 66: 401-405.

• Govindarajan R, Asare-Anane H, Persaud S, Jones P, Houghton PJ., (2007) Effect of Desmodium gangeticum Extract on Blood Glucose in Rats and on Insulin Secretion in vitro. Planta Med. 2007 May;73(5):427-32.

• Meenakshi Singh, Rawat, AKS, Govindarajan R., (2007) Antimicrobial activity of 15 Indian mosses. Fitoterapia. 78(2):156-158.

• Govindarajan, R., Singh, D.P., Rawat, A.K.S. (2007) High Performance Liquid Chromatographic method for the quantification of phenolics in ‘Chyavanprash’ a potent Ayurvedic drug. Journal of Pharmaceutical Biomedical Analysis. 43:527-532

  2006

• Sreevidya, N., Govindarajan, R., Vijayakumar, M., M. Thakur, V.K., Dixit, S. Mehrotra, K.P. Madhusudanan (2006) Action of fructo-oligo polysaccharide fraction of Chlorophytum borivilianum against streptozotocin induced oxidative stress. Planta Medica 72: 1421-1424.

• P. J. Houghton, V. Kumar, R. Govindarajan, P. K Mukherjee (2006) Asarones in Acorus calamus and their acetylcholinesterase inhibition. Journal of Pharmacy and Pharmacology. Supplementary A-56.

• R. Govindarajan, M. Vijayakumar, A. Shirwaikar, A.K.S. Rawat, S. Mehrotra, P. Pushpangadan (2006) Antioxidant activity of Desmodium gangeticum and its phenolics in arthritic rats. Acta Pharmaceutica 56: 489-496.

• M. Singh, R. Govindarajan, V. Nath, AKS Rawat, S. Mehrotra (2006) Antimicrobial, wound healing and antioxidant activity of Plagiochasma appendiculatum Lehm. et Lind. Journal of Ethnopharmacology 107: 67-72.

• Govindarajan, R., Vijayakumar, M., Singh, M., Rao, Ch.V., Shirwaikar, A., Pusphangadan, P. (2006) Antiulcer and antimicrobial activities of Anogeissus latifolia. Journal of Ethnopharmacology 106:57-61.

• Pandey, Madan Mohan, Govindarajan, R., Khatoon, Sayyada, Rawat, A.K.S. and Mehrotra, Shanta. Comparative Pharmacognostical evaluation of Polygonatum species viz. Polygonatum cirrhifolium and Polygonatum verticilatum. Journal of herbs spices and medicinal plants 11(2):37-42.

• Mishra S, Srivastava S, Tripathi RD, Govindarajan R, Kuriakose SV, Prasad MN. 2006. Phytochelatin synthesis and response of antioxidants during cadmium stress in Bacopa monnieri L. Plant Physiol Biochem. 2006 Jan;44(1):25-37.

• Vijayakumar, M., Govindarajan, R., Rao, Ch. V., Shirwaikar, A., Mehrotra, S., Pushpangadan, P. (2006) Action of Hygrophila auriculata on antioxidant enzymes in diabetic rats. J. Ethnopharmacol.104: 356-361.

• Sreevidya, N., Govindarajan, R., Vijayakumar, M., Mehrotra, S., 2006. Antioxidant activity of Chlorophytum tuberosum. Journal of Ethnopharmacology. 104:423-425.

  2005

  Govindarajan, R., Sreevidya, N., Vijayakumar, M., Thakur, M., Dixit, V.K., Mehrotra, S. (2005) In vitro antioxidant activity of ethanolic extract of Chlorophytum borivillianum. Natural product Sciences 11(3): 165-169.

• Pandey, M. M., Govindarajan, R., Rawat AKS., Pushpangadan, P., Free radical scavenging potential of Saussarea costus. Acta Pharmaceutica 55(3): 179-185.

• Vijayakumar, M., Govindarajan, R., Shirwaikar, A., Vivek Kumar, Rawat, A. K. S., Mehrotra, S., Pushpangadan, P. (2005) Free radical scavenging and lipid peroxidation inhibition potential of Hygrophila auriculata. Natural Product Sciences. 11(1): 22-26.

  2004

  Govindarajan, R., Vijayakumar, M., Rawat, AKS., Shirwaikar, A., Mehrotra, S., Pushpangadan, P. (2004) Activity guided isolation of antioxidant tannoid principles from Anogeissus latifolia. Natural Product Sciences 11(3): 174-178.

• Solairaj, P., Bhat, A. R., Suvarna. G. Kini, Govindarajan, R and Venkatraman, R. (2004) HPTLC method for the estimation of fexofenadine HCl in tablet dosage form. Indian Drugs. (Accepted).

• Govindarajan, R., Vijayakumar, M., Rao, Ch. V., Shirwaikar, A., Mehrotra, S., Pushpangadan, P. (2004) Healing potential of Anogeissus latifolia for dermal wounds in rats. Acta Pharmaceutica 54: 331-338.

• Rastogi, S., Shashi Bala, Govindarajan, R., Shukla, M., Rawat, A. K. S., Mehrotra, S. (2004) Quantitative HPLC Analysis of Amino Acids in Chyavanprash: A well known Ayurvedic Formulation. Indian Journal of Pharmaceutical Sciences 66(12): 38-42.

• Govindarajan, R., Vijayakumar, M., Rao, Ch. V., Rawat, A. K. S., Shirwaikar, A., Mehrotra, S., Pushpangadan, P. (2004) Antioxidant potential of Anogeissus latifolia, Biological Pharmaceutical Bulletin 27(8):1266-1269.

• Govindarajan, R., Vijayakumar, M., Rao, Ch. V., Vivek Kumar, Rawat, A. K. S., Pushpangadan, P. (2004) Action of Asparagus racemosus against streptozotocin induced oxidative stress. Natural Product Sciences. 10(4): 177-181.

• Ch.V.Rao, S.K.Ojha, K.Radhakrishnan, R. Govindarajan, S. Rastogi, S. Mehrotra and P. Pushpangadan. (2004) Antiulcer activity of Utleria salicifolia rhizome extract. Journal of Ethnopharmacology 91: 243-249.

• Govindarajan, R., Agnihotri, A.K., Rawat, A.K.S., Khatoon, S. and S. Mehrotra. (2004) Pharmacognostic evaluation of an antioxidant plant – Acorus calamus Linn. Natural Product Sciences 9(4): 264-269.

• Snehi, S. K., Govindarajan, R., Singh, D. P., Mehrotra, S. (2004) Antibacterial activity of Desmodium gangeticum. Lucknow Journal of Sciences. 1: 15-18.

• Shashi Bala, Govindarajan, R., Rawat, A.K.S., Mehrotra, Shanta. (2004) High performance liquid chromatographic analysis of withaferin A in Withania somnifera (L.) Dunal. Indian Journal of Pharmaceutical Sciences. Mar-Apr. 527-529.

• M. M. Pandey, R. Govindarajan, A.K.S. Rawat, Y.P.S. Pangtey and S. Mehrotra. (2004) High performance Liquid Chromatographic method for quantitative estimation of an antioxidant principle chlorogenic acid in Saussarea costus and Arctium lappa. Natural Product Sciences. 10(2): 40-42.

  2003

• Govindarajan, R., Rastogi, S., Vijayakumar, M., Rawat, A. K. S., Shirwaikar, A., Mehrotra, S., Pushpangadan, P. (2003) Studies on the antioxidant activities of Desmodium gangeticum, Biological Pharmaceutical Bulletin 26(10):1424-1427.

• Govindarajan, R., Vijayakumar, M., Rawat, A.K.S. and Mehrotra, Shanta. (2003) Free radical scavenging potential of Picrorrhiza kurrooa. Indian J. Exp. Biol. Vol 41. 875-879.

• Sirish Kumar, I. V. M. L. R., Paul, B. N., Asthana, R., Saxena, A., Mehrotra, S., Govindarajan, (2003) Swertia chirayita mediated modulation of Interleukin-1β Interleukin-6, Interleukin-10, Interleukin-γ, and tumor necrosis factor-α in arthritic mice. Immunopharmacology and Immunotoxicology 25(4): 573-583.

• Govindarajan, R., Beena, T., and Bhat A. R. (2003) Synthesis and antitubercular activity of thiazolidinone related compounds. Heterocyclic communiucations., 9(3): 259-264.

• Rao, Ch.V., Govindarajan, R., Mehrotra, S., Pushpangadan, P. (2003) Querecetin, a bioflavonoid, protects against oxidative stress-related gastric mucosal damage in rats. Natural Product Sciences 9(2):1-5.

• Govindarajan, R, Jameela H. J., and Bhat, A. R. Design and synthesis of azetidinone and thiazolidindone derivative of pyrazinoic acid for possible antitubercular, antifungal and antibacterial activity, (2003) Indian Journal of Heterocyclic Chemistry, Vol 12 (3): 247.

  2002

  Govindarajan, R and Bhat A. R. (2002) Synthesis of pyrazinoyl and related heterocycles as possible antitubercular agents Indian Journal of Heterocyclic Chemistry Vol 11, 337-339.

Chapters in Books

• Chemical standardization of herbal drugs. Subha Rastogi and R. Govindarajan (2003) In Post Harvest Technology of Medicinal and Aromatic Plants. National Botanical Research Institute, Lucknow

• Bioinformatics and documentation of Nutraceuticals. Pushpangadan, P. and Govindarajan, R. (2005). In Medicinal Plants of Kerala: Conservation and Benefication. Kerala State Council for Science & Technology and Environment, Thiruvananthapuram, Kerala.

• Need for scientific validation and standardization of traditional medicine to meet the healthcare of the third world in 21st century. P. Pushpangadan and R. Govindarajan. In: Herbal medicine phytopharmaceuticals and other natural products: Trends and advances, NAM S&T centre and Institute of chemistry, Ceylon, Srilanka, pp. 247-257.

• Antioxidant approach to disease management with special emphasis on herbal drugs. R Govindarajan and M. Vijayakumar. In: Herbal drugs A twenty First Century Perspective, Jaypee Brothers, New Delhi

• Chemical standardization of herbal drugs with special emphasis on chromatography. R Govindarajan and M. Vijayakumar. In: Herbal drugs A twenty First Century Perspective, Jaypee Brothers, New Delhi

• Need for Developing Protocol for collection/ cultivation and quality parameters of medicinal plants for effective regulatory quality control of herbal drugs. P. Pushpangadan and R Govindarajan (2005) In: Proceedings – international conference of botanicals, Kolkata, India

Conference Papers

• Govindarajan, R., Vijayakumar, M., Rao, Ch. V., Rawat, A. K. S., and Pushpangadan P.  Effect of Desmodium gangeticum on Antioxidant Enzymes in Streptozotocin -Induced Diabetic Rats. Society for Free radical Research Congress. Bangalore, January 2005.

• R. Govindarajan, M. Vijayakumar, A. K. S. Rawat and Shanta Mehrotra. Antioxidant Defenses with Special Emphasis on Role of Plant Phenols as Antioxidants. National Seminar on New Millennium strategies for Quality, Safety and GMPs of Herbal Drugs/ Products, held at National Botanical Research Institute, Lucknow on Nov. 11-13, 2003.

• R Govindarajan, M. Vijayakumar, S K Ojha, Ch. V. Rao and S. Mehrotra, Antioxidant and anti-inflammatory activity of the Desmodium gangeticum.. Southern Regional Conference Of The Indian Pharmacological Society – 2003,Tirupathi, 12-14 September 2003

• R. Govindarajan, Subha Rastogi, A.K.S. Rawat and Shanta Mehrotra. Comparative antioxidant studies of Rubia cordifolia Linn. collected from different geographical zones. 2nd World Congress on Biotechnological Development of Herbal Medicine, Feb. 20-22, 2003 at NBRI, Lucknow.

• R. Govindarajan, S. Rastogi, A.K.S. Rawat, S. Mehrotra and P. Pushpangadan. Antioxidant activity of ‘Kutki’-Picrorhiza kurroa.  3rd world congress on medicinal and aromatic plants, Chiang Mai, Thailand, Feb 3-7, 2003.

• R. Govindarajan, M. Vijayakumar, A.K.S. Rawat and S. Mehrotra. Hydroalcoholic extract of Picrorhiza kurroa root – a potent antioxidant. 54th Indian Pharmaceutical Congress 2002, held at Pune on December 13th –15th -2002.

• R. Govindarajan, Antioxidant activity of Acorus calamus. International Congress on Traditional Asian Medicine, Halle, Germany, August 18-24, 2002.

• R Govindarajan, Subha Rastogi, S. Mehrotra and P. Pushpangadan Chemical standardisation – A present day need.. 1st international Siddha Congress, Kilavayal, Tamil Nadu, May 24-26, 2002.

• R Govindarajan, A.K.Agnihotri, M.M.Pandey, S.Khatoon, S. Mehrotra and P.Pushpangadan, Quality evaluation of “Vidarikhand”, 53rd Indian Pharmaceutical Congress, New Delhi, Dec 21- 23, 2001

• Around 15 more coauthored conference papers

Invited lectures

• Quality control and Standardization of Herbal drugs in “Biodiversity and Sustainable utilization of medicinal plants in Uthranchal” held in DehraDun, sponsored by Oxfam.

• Chemical standardization of herbal drugs. in Post Harvest Technology of Medicinal and Aromatic Plants. National Botanical Research Institute, Lucknow.

• In the workshop on “Pilot plant scale up and marketing of new pharmaceutical” organized by ISTE held at College of Pharmaceutical Sciences, Manipal, delivered two lectures entitled “Herbal medicine in Pharmacy – a modern perspective” and “Chemical standardisation – a present day need”

Patents

1. Novel Health promoting functional foods fortified with herbs. Palpu Pushpangadan, Ajay Kumar Singh Rawat, Chandana Venkateswara Rao, Sharad Kumar Srivastava, Raghavan Govindarajan (384NF 2004)

2. Anticigarette herbal formulation as an antidote to tobacco. Arun Kumar Karerat  , Mohammad Istikar, Joy Varghese (MIR Holistics, INDIA), Vellappillil AchuthanVenugopal, Palpu Pushpangadan, Ajay Kumar Singh Rawat, Chandana Venkateswara Rao, Raghavan Govindarajan. (386NF 2004).

3. Novel Herbal Composition as Memory enhancer in Alzheimers condition Palpu Pushpangadan, Chandana Venkateswara Rao, Kamal Kishore, Yogendra Kumar Gupta, Ramasami Kartik, Raghavan Govindarajan (383NF 2004)

4. Development of anticough, anti-tussive and throat soothing herbal formulation. Pushpangadan, P., Govindarajan, R., Vijayakumar, M., Mehrotra S., and Rao, Ch.V.. (PCT International application No. WO2004058283 - 2004-07-15,  IPMD No. 573-NF/2002)

5. Anti-ulcer herbal composition. Pushpangadan, P., Rao, Ch.V., Radhakrishnan, K. Nair, Govindarajan, R. and Mehrotra S. (PCT International application No. WO2004056381 - 2004-07-08, IPMD No. 574-NF/2002)

6. Pushpangadan, P., Rao, Ch.V., Govindarajan, R. Padmavathi, P. Rawat AK.S. Ojha, S. K. Mehrotra S. AntiHyperlipidemic herbal composition(s) (IPMD No. 473-NF/2003)

7. Pushpangadan, P., Rao, Ch.V., Govindarajan, R. and Rawat AK.S. Ojha, S. K. Mehrotra S. Antiarthritic herbal composition(s) (IPMD No. 474-NF/2003).

8. Safe, eco-friendly, health protective, herbal colours and aroma useful for cosmaceutical application. Pushpangadan, P., Mehrotra, S., Rawat, A. K. S., Khatoon, Sayyada, Govindarajan, R. (U. S. application No. and PCT International application No. 09/846,270).

9. Colori E Profumi Di Origine Erbacea Dotati Di Proprieta' Di Sicurezzae Protezione Della Salute, Ecologicamente Accettabili, Utili Per Appli. Govindarajan Raghavan; Khatoon Sayyada; Mehrotra Shanta; Pushpangadan Palpu; Rawat Ajay Kumar Singh. (ITRM20010173 - 2002-09-30).

10. Extraction Of Non-Toxic Vegetable Dyes, For Use In Lipsticks Or Other Cosmetics, By Extracting Parts Of Plants, Especially Of The Boraginaceae Family, With Organic Solvent And Concentrating The Extract. Govindarajan Raghavan; Khatoon Sayyada; Mehrotra Shanta; Pushpangadan Palpu; Singh Rawat Ajay Kumar. (FR2822677 - 2002-10-04).