List of my work:

Fibrinolysis in cutaneous vasculitis

Abstract

Abnormal fibrinolysis, determined by the relative concentrations of plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1), has been demonstrated in patients with cutaneous necrotizing vasculitis (CNV). ELISA tests were performed to detect levels of plasma t-PA & PAI-1 in 40 patients and 13 controls. Post-occlusive t-PA & PAI-1 levels were measured in 9 patients and 6 controls. Patients were subdivided into two groups; early: lesion duration < 2 weeks and late: lesion duration ³ 2 weeks. Results of the study show an early hyperfibrinolytic stage with high t-PA and a late hypofibrinolytic stage with low t-PA . No significant changes were detected in PAI-1 levels in both groups. Post-occlusive t-PA & PAI-1 levels were significantly elevated than pre-occlusive levels. It is concluded that there exists a dynamic state in the fibrinolytic system in case of CNV; an early hyperfibrinolytic stage and a late hypofibrinolytic stage.

Key words:

cutaneous necrotizing vasculitis; Fibrinolysis; fibrin degraded products (FDP); tissue plasminogen activator (t-PA); plasminogen activator inhibitor 1 (PAI-1).

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