===========================================================
8.) Benign Leydig cell tumor of the testis
associated with humanpapillomavirus type 33
presenting with the sign of
Leser-===========================================================
Trelat.
J Urol 1993 Oct;150(4):1246-50 Related
Articles, Books
Martin RW 3d, Rady P, Arany I, Tyring SK
Department of
Dermatology, Johns Hopkins School of Medicine,
Baltimore,Maryland.
We present a case
of a benign testicular Leydig cell tumor and eruptive seborrheic keratosis associated with human
papillomavirus type 33infection. To our knowledge
this is the first occurrence of a Leydigcell tumor
in a patient with tuberous sclerosis and the second
documented case of eruptive seborrheic keratoses (sign
of Leser-Trelat)associated with a benign neoplasm.
===========================================================
9.) A case of pancreatic cancer with the sign of
Leser-Trelat.
===========================================================
Nippon Geka Hokan 1993 Jul 1;62(4):203-8 Related
Articles, Books
Hirano T, Yoshioka H, Manabe T
Department of Surgery, Yoshioka Hospital, Kyoto,
Japan.
A case of
79-year-old man with pancreatic cancer associated with
thesign of Leser-Trelat was presented. Abdominal CT
scanning was performedand a pancreatic tail tumor
involving the spleen and the greater omentumas well
as ascitic retention were detected. Ba-enema study
showed thestenosis of the sigmoid colon, suggesting
the peritoneal disseminations.Absolute non-curative
operation of side-to-side transverso-sigmoidostomy
was performed for colonic stenosis, and biopsy of the
disseminatedomental tumor was performed, which was
histologically diagnosed as welldifferentiated
papillary adenocarcinoma compatible with pancreatic
cancer. The postoperative course was uneventful and at
present thepatient was followed at outpatient
clinic. To our knowledge, this caseis the first
report with pancreatic cancer associated with the sign
ofLeser-Trelat in Japan.
===========================================================
10.) The sign of Leser-Trelat: a cutaneous sign of
internal malignancy:weakened subepithelial matrix
from the effect of neoplasms on theextracellular
matrix of the host.
===========================================================
Med Hypotheses 1993 Jun;40(6):360-3
Stone OJ
The sudden onset
of many seborrheic keratoses (SK) associated with an
internal malignancy (most commonly adenocarcinoma) is
called the sign ofLeser-Trelat. It is associated
with acanthosis nigricans (AN) in 20% ofthe cases.
There are marked changes in the extracellular matrix
(ECM)around tumors. Various fractions and
depolymerized glycosaminoglycansenter circulation.
They can incorporate in the general extracellular
matrix. Mechanical factors present in AN produce
extrusions of this poorquality ECM in the form of
papillae and folds. The poor quality of
subepithelial extracellular matrix produces the marked
epithelialchanges of acanthosis nigricans which
shows hyperkeratosis,papillomatosis, slight
irregular acanthosis, and keratin material
formation. The neoplasm can produce the same qualitative
changes in thesubepithelial ECM on otherwise normal
appearing skin. When the alteredsame epithelial
changes occur on this biologically altered skin the
result is many SK (the sign of Leser-Trelat).
===========================================================
11.) [Skin manifestation of internal malignancy].
===========================================================
Gan To Kagaku Ryoho 1991 Mar;18(3):365-70 Related
Articles, Books
Nishiyama S
Department of
Dermatology, School of Medicine, Kitasato University,
Sagamihara, Japan.
Relationship
between malignant tumor of the internal organ and the
skincan be classified as skin metastasis of the
malignant tumor,non-specific skin manifestation of
the malignant tumor and hereditarysyndrome which
tends to have malignant tumor. I, however, discuss here
mainly about the non-specific manifestation of the
malignant tumor byshowing representative cases of
the dermadrome. Such cases areacanthosis nigricans,
Leser-Trelat's sign, dermatomyositis, atypical
erythema, acquired ichthyosis, Sweet's disease,
Weber-Christian'ssyndrome, phlebitis migrans and
Bazex syndrome.
===========================================================
12.) Leser-Trelat sign associated with Sezary
syndrome.
===========================================================
SO - J Dermatol 1995 Jan;22(1):62-7
AU - Ikari Y; Ohkura M; Morita M; Seki K; Kubota
Y; Mizoguchi M
PT - JOURNAL ARTICLEAB
- A 74-year-old Japanese male had developed generalized
erythrodermaand rapid growth of multiple verrucous
lesions over the entire surfaceof his face, trunk,
and extremities three months before he was seen.
Histologically seborrheic keratoses were revealed.
Laboratoryexaminations showed peripheral
leukocytosis with atypical lymphocytesand high
levels of IgE and IgG. On the basis of these clinical
andhistopathologic findings, we diagnosed the
patient as havingLeser-Trelat sign associated with
Sezary syndrome. The erythrodermasubsided after
administration of oral predonisone, and no new
formationsof seborrheic keratosis were observed.
However, because of subsequentaggravation of the
generalized erythroderma, we administered
chemotherapy. Six months after the initial examination,
lung cancer wasfound, and the patient subsequently
died of respiratory and renalfailure.
===========================================================
13.) The sign of Leser-Trelat associated with
transitional cellcarcinoma of the
urinary-bladder--a case report and short review.
===========================================================
SO - Clin Exp Dermatol 1994
Mar;19(2):142-5
AU - Yaniv R; Servadio Y;
Feinstein A; Trau H
PT - JOURNAL ARTICLE;
REVIEW (28 references);
REVIEW OF REPORTED CASES
AB
- Leser-Trelat sign is defined as the sudden appearance
of multipleseborrhoeic keratoses in association
with internal malignancy. Although75 cases have
been reported to date, controversy still exists about
thesignificance of this sign. The first association
of the Leser-Trelatsign with transitional cell
carcinoma of the urinary-bladder isreported.
===========================================================
14.) Mycosis fungoides with Leser-Trelat sign: the
first report of apatient from Japan.
===========================================================
SO - J Dermatol 1994 Mar;21(3):189-93
AU - Miyako F; Dekio S; Tamura H; Yamada Y;
Miyata N; Jidoi J; Tohgi KPT - JOURNAL
ARTICLEAB -
We describe here a 35-year-old
Japanese woman with mycosisfungoides (MF) who
developed numerous, rapidly-growing, seborrheic
keratoses on the front of her neck and chest. To the
best of ourknowledge, this is the first reported
case of MF with Leser-Trelat signfrom Japan.
===========================================================
15.) The sign of Leser-Trelat associated with
adenocarcinoma of the rectum.
===========================================================
SO - Cutis 1993 Apr;51(4):255-7
AU
- Cohn MS; Classen RF
PT - JOURNAL ARTICLE
AB - The authors report a case of the sign of
Leser-Trelat occurring ina patient with primary
adenocarcinoma of the rectum. The patient
demonstrated the sign several months before the internal
malignancy wasdiscovered. Although the majority of
patients with the sign have anunderlying
adenocarcinoma of the gastrointestinal tract, relatively
fewcases have been reported with the rectum as the
primary site. This casedemonstrates a classic
example of the sign of Leser-Trelat andillustrates
its importance as a marker of underlying malignancy.
===========================================================
16.) Seborrheic keratoses and cancer.
===========================================================
SO - J Am Acad Dermatol 1992
Jun;26(6):947-50
AU - Lindelof B;
Sigurgeirsson B; Melander S
PT - JOURNAL
ARTICLE
AB - BACKGROUND:
The eruptive
appearance of numerous seborrheickeratoses, the
sign of Leser-Trelat, has been regarded as a reliable cutaneous marker of internal malignancy.
OBJECTIVE:
We have evaluatedthe possible association of
malignant disease and the sign in 1752consecutive
cases of seborrheic keratoses.
METHODS:
First, the
SwedishCancer Registry was searched for records of
malignancies in the studypopulation (1958 to 1984),
and the expected number of malignancies was
calculated. Second, records of persons with malignancy
within 1 yearbefore or after the diagnosis of
seborrheic keratosis were checked forthe sign of
Leser-Trelat. Third, a case control study was performed
toevaluate the possibility of eruptive seborrheic
keratoses among thenoncancer patients in the study
population.
RESULTS:
The results showeda slight
increased risk of cancer in the study population
(relative risk= 1.2; 95% confidence interval = 1.0
to 1.3), mainly because of anincreased risk of
cutaneous squamous cell carcinoma. In 62 patients with seborrheic keratoses, a malignancy (excluding skin)
was diagnosed within1 year before or after the
diagnosis of seborrheic keratosis. Of these62
patients, 6 were regarded as possibly having presented
with the signof Leser-Trelat. For every one of the
62 cases with seborrheic keratosisand malignancy
within one year, an age- and sex-matched control patient without cancer was selected from the study
population and the recordswere checked for sudden
and eruptive seborrheic keratoses. Among thecontrol
patients, five were regarded as possibly having
presented withthe sign of Leser-Trelat.
CONCLUSION:
This study gives no evidence tosupport the opinion
that eruptive seborrheic keratoses are related to
internal cancer risk.
===========================================================
17.) The sign of Leser-Trelat in a young woman with
osteogenic sarcoma.
===========================================================
SO - J Am Acad Dermatol 1992 Feb;26(2 Pt
2):344-7
AU - Barron LA; Prendiville JS
PT
- JOURNAL ARTICLE
AB - The sign of
Leser-Trelat refers to a sudden increase in size and
number of seborrheic keratoses associated with internal
malignancy. Thevalidity of this cutaneous sign
continues to be debated, particularlybecause of the
prevalence of both seborrheic keratoses and malignancy
inthe elderly population. Preceding inflammatory
skin conditions are knownto precipitate eruptions
of seborrheic keratoses in otherwise healthy
persons. These cutaneous lesions may also be associated
with othermarkers of underlying malignancy such as
acanthosis nigricans. Wepresent a young female
patient with osteogenic sarcoma in whom eruptive
seborrheic keratoses developed. We believe this case is
representativeof the sign of Leser-Trelat.
===========================================================
18.) Sign of Leser-Trelat with a metastatic mucinous
adenocarcinoma.
===========================================================
SO - Cutis 1991 Apr;47(4):258-60
AU
- Schwartz RA; Helmold ME; Janniger CK; Gascon P
PT
- JOURNAL ARTICLE
AB - We describe a
middle-aged woman with the sudden onset of multiple
seborrheic keratoses in association with a metastatic
mucinousadenocarcinoma to the liver from an unknown
primary neoplasm. This caseillustrates the
significance of the sign of Leser-Trelat and its
association with cancer.
===========================================================
19.) The sign of Leser-Trelat: does it exist? [see
===========================================================
comments]SO - J Am Acad Dermatol
1989 Jul;21(1):50-5AU - Rampen HJ; Schwengle
LEPT - JOURNAL ARTICLE; REVIEW (51
references);
REVIEW OF REPORTED CASESAB - The
sign of Leser-Trelat is usually regarded as a reliable cutaneous marker of internal malignancy. We have
reviewed the literatureand conclude that the
evidence for a causal relation between eruptive
seborrheic keratoses and cancer is meager.
===========================================================
20.) The sign of Leser-Trelat associated with
malignant melanoma.
===========================================================
SO - Cutis 1989 Jul;44(1):39-41
AU
- Fanti PA; Metri M; Patrizi A
PT - JOURNAL
ARTICLEAB -
A case of the sudden appearance
of multiple pruritic seborrheickeratoses
(Leser-Trelat sign) associated with cutaneous malignant melanoma is reported. To the authors' knowledge,
this association hasnot been previously reported.
===========================================================
21.) Paraneoplastic rhinophyma and the Leser-Trelat
sign.
===========================================================
SO - Clin Exp Dermatol 1989
May;14(3):253-5AU - Mayou SC; Benn JJ;
Sonksen PH; Black MMPT -
JOURNAL ARTICLE
AB - A case of the Leser-Trelat sign associated
with an underlyingmalignant haemangiopericytoma is
described. In addition, the patient hadprofound
hypoglycaemia and a rhinophyma-like nasal swelling which rapidly resolved post-operatively.
The tumour
appeared to be secreting afactor(s) which
cross-reacted with both insulin receptors to induce
hypoglycaemia and epidermal growth factor receptors
inducing a profusionof eruptive seborrhoeic warts.
It aslo had marked sebotrophic activity.The
association of the Leser-Trelat sign with malignant
haemangiopericytoma has not previously been described.
===========================================================
22.) Transformation of lymphocytoma cutis into a
malignant lymphoma inassociation with the sign of
Leser-Trelat.
===========================================================
SO - Acta Derm Venereol 1987;67(2):172-5
AU - Halevy S; Sandbank MPT -
JOURNAL ARTICLEAB - A patient is described in
whom transformation of lymphocytomacutis (LC) into
malignant lymphoma, diffuse, mixed small and large
lymphocytes, occurred in association with the sign of
Leser-Trelat (LT),which is a marker for internal
malignancy. To the best of our knowledge,such an
association has not been reported previously.
===========================================================
23.) Leser-Trelat sign associated with Sezary
syndrome.
===========================================================
SO - Cutis 1985 Nov;36(5):409-10
AU
- Horiuchi Y; Katsuoka K; Tsukamoto K; Takezaki SPT
- JOURNAL ARTICLEAB - The Leser-Trelat sign
is a rare but well known cutaneous indicatorof
internal malignancy, most commonly adenocarcinoma of the
stomach.There have been only a few cases associated
with lymphoproliferativemalignancies. Sezary
syndrome is a chronic leukemia/lymphoma
characterized by generalized erythroderma and
circulating Sezary cells.We describe a rare case of
the Leser-Trelat sign associated with theSezary
syndrome. The skin sign was alleviated through
combinationchemotherapy.
===========================================================
24.) The sign of Leser-Trelat associated with
primary lymphoma of thebrain.
===========================================================
SO - Cutis 1984 Aug;34(2):164-5
AU
- Kaplan DL; Jegasothy B
PT - JOURNAL ARTICLE
AB - The sign of Leser-Trelat has been defined
as the sudden appearanceof seborrheic keratoses in
number and/or size in association with anunderlying
malignancy. There have been only thirty-two reported
cases ofthe sign of Leser-Trelat since it was first
described in 1984. This isthe first known case of
primary lymphoma of the brain associated withthis
sign. Until Dantzig's review of the literature in 1973,
the onlytumor type associated with this sign had
been adenocarcinomas of thegastrointestinal tract
and the genitourinary tract. Since that timethere
have been only nine cases reported that were not
adenocarcinomas;of those, only four cases have been
lymphoproliferative malignancies. Wewish to
emphasize the need for further reports of this sign to
bettercharacterize it and to make physicians more
aware of the associationbetween this dermatologic
sign and an internal malignancy.
===========================================================
25.) Acanthosis nigricans and the sign of
Leser-Trelat associated withadenocarcinoma of the
gallbladder.
===========================================================
SO - Cancer 1981 Jul 15;48(2):325-8
AU - Jacobs MI; Rigel DS
PT - JOURNAL
ARTICLE
AB - A case of adenocarcinoma of the
gallbladder associated withacanthosis nigricans and
the sign of Leser-Trelat is presented. The
significant underrepresentation of adenocarcinoma of the
gallbladder inassociation with malignant acanthosis
nigricans is noted. If malignantacanthosis
nigricans is caused by an ectopic peptide, a relative
lack ofproduction of the postulated substance by
gallbladder adenocarcinomacells could account for
this finding.
===========================================================
26.) Bile duct adenocarcinoma with Leser-Trelat sign
and pure red bloodcell aplasia.
===========================================================
SO - Cancer 1980 Oct 1;46(7):1657-60
AU - Lee CH; Clark AR; Thorpe ME; Mackie BS;
Firkin FC
PT - JOURNAL ARTICLE
AB -
A case of adenocarcinoma of the bile duct complicating longstanding ulcerative colitis and associated with
the rapid onset andgrowth of multiple seborrheic
keratosis (Leser-Trelat sign) and pure redblood
cell aplasia is described. This is the first report of a
case ofthe coexistence of the Leser-Trelat sign and
pure red blood cell aplasiain a patient with a
malignancy. Both manifestations have been doubted as
truly paraneoplastic manifestations because of their
rarity in clinicalmedicine. Their co-existence in
the present case would support theirassociaton with
malignancy.
===========================================================
27.) The sign of Leser-Trelat. Report of a case with
adenocarcinoma ofthe duodenum.
===========================================================
SO - Arch Dermatol 1980
Sep;116(9):1059-60
AU - Curry SS; King LE
PT - JOURNAL ARTICLE
AB - The sign of
Leser-Trelat is a rare cutaneous manifestation of
internal malignancy. Although adenocarcinoma is the most
commonmalignant neoplasm associated with the sign
of Leser-Trelat, we reportwhat we believe to be the
first case of adenocarcinoma of the duodenum
associated with this sign. Because of the location of
the tumor, weconsidered the possibility that the
skin changes may be due to increasedlevels of
epidermal growth factor (EGF) in this patient. However,
noalteration in urine EGF levels was found.
===========================================================
28.) [The Leser-Trelat symptom: report of two cases
===========================================================
(author's transl)]
SO - Ann Dermatol
Venereol 1980;107(11):1035-41
AU -
Lambert D; Fort M; Legoux A; Chapuis JL
MC -
English AbstractPT -
JOURNAL ARTICLE; REVIEW
(22 references)
AB - The sudden occurrence and
rapid increase in size and number ofseborrheic
keratoses is considered to be a symptom of internal
malignancy. But many authors did not fully agree with
this finding. Wereport two cases respectively
associated, the first with a mycosisfongoides, the
second with a bronchial squamous cell carcinoma. These
observations are compared with thin cases previously
published in thedermatological literature (13
patients). According to Dantzig thecommonest
associated malignancy is an adenocarcinoma, and the most frequent site the stomach. But there are also report
of acute leukemia,mycosis fongoides, Sezary and
lymphocytic lymphoma. The mechanism of the
simultaneous growth of the lesions remains unknown and
may be purelycoincidental. Other case reports and
several criteria still to bedefined are needed
before we accept this symptom as a malignancy marker.
===========================================================
29.) Adenocarcinoma of the stomach with eruptive
seborrheic keratoses:the sign of Leserp-Trelat.
===========================================================
SO - Cancer 1980 May 1;45(9):2434-7
AU - Sperry K; Wall J
PT - JOURNAL
ARTICLE
AB - The sign of Leser-Trelat, the
sudden appearance of multipleseborrheic keratoses
in conjunction with an internal malignancy, is very
uncommon. A case involving a patient who had undergone
resection of anadenocarcinoma of the sigmoid colon
followed ten years later by thedevelopment of an
adenocarcinoma of the stomach with exhibition of the
sign of Leser-Trelat is presented. A summary of reported
cases, alongwith a discussion of the sign, is
provided. This is the first reportedcase of a
patient presenting with the sign of Leser-Trelat along
with asecond primary malignancy.
===========================================================
30.) Florid cutaneous papillomatosis, malignant
acanthosis nigricans,and pulmonary squamous cell
carcinoma.
===========================================================
SO - Int J Dermatol 1991 Mar;30(3):193-7
AU - Gheeraert P; Goens J; Schwartz RA;
Lambert WC; Schroeder F;
Debusscher L
PT -
JOURNAL ARTICLE; REVIEW (25 references);
REVIEW OF
REPORTED CASES
AB - A 72-year-old man had
florid cutaneous papillomatosis (FCP), whichis an
obligatory paraneoplastic syndrome always associated
with aninternal malignancy. The cancer, which is
usually intraabdominal andmost often gastric in
origin, evolves parallel to the FCP. This patientis
the first case of FCP occurring in association with a
lungmalignancy. An association of FCP with other
signs of internal cancer iscommon, with malignant
acanthosis nigricans usually appearing many times
with the sign of Leser-Trelat. FCP, malignant acanthosis
nigricans, andthe sign of Leser-Trelat are part of
a continuum, developing by a commonor similar
pathogenic pathway due to an underlying malignancy
producinga factor possibly similar to human
epidermal growth factor.
===========================================================
31.) The relation between seborrheic keratoses and
malignant solidtumours. A case-control study.
===========================================================
SO - Acta Derm Venereol 1991;71(2):166-9
AU - Grob JJ; Rava MC; Gouvernet J; Fuentes P;
Piana L; Gamerre M;Sarles JC; Bonerandi JJPT
-
JOURNAL ARTICLE
AB - In order to establish
whether or not here is an associationbetween cancer
and intense growth of seborrheic keratosis, the
so-calledLeser-Trelat sign, we conducted a case
control study in which the numberand features of
seborrheic keratosis in 82 patients with recent solid
tumours, were compared with 82 age- and sex-matched
controls. Neithernumbers nor features of seborrheic
keratosis differed significantly inpatients and
controls. Eruptive seborrheic keratosis was noted in
onlyone patient and one control. This study showed
that solid malignanciesare not generally associated
with an increase in the number or size ofseborrheic
keratosis lesions, thus suggesting that they are not
controlled by a hypothetical secretion of growth factors
by tumours. Ourresults suggest that Leser-Trelat is
either a coincidence, or at most avery rare sign of
unusual types of cancer. We also showed that multiple cherry angiomas, previously reported to be a
paraneoplastic sign, arenot regularly associated
with solid tumours.
===========================================================
32.) Transformation of Sezary syndrome and the sign
of Leser-Trelat: ahistopathologic study.
===========================================================
SO - J Am Acad Dermatol 1990 Sep;23(3 Pt
1):520-2
AU - Wieselthier JS; Bhawan J; Koh HK
PT - JOURNAL ARTICLE
===========================================================
33.) Sign of Leser-Trelat: report of two cases and
review of the
literature.
===========================================================
SO - J Am Acad Dermatol 1984
Jan;10(1):83-8
AU - Venencie PY; Perry HO
PT - JOURNAL ARTICLE
AB - The sudden
appearance of multiple seborrheic keratoses in the two
patients could be related to adenocarcinoma of the
breast. Despite other
isolated reports, this
disorder is still controversial as a marker of
malignancy.
===========================================================
34.) Pemphigus foliaceus resembling eruptive
seborrheic keratoses.
===========================================================
SO - Arch Dermatol 1980 Jul;116(7):815-6
AU - Bruckner N; Katz RA; Hood AF
PT
- JOURNAL ARTICLEAB - A 78-year-old man had
an acute eruption of lesions that clinically
resembled seborrheic keratoses. Microscopic examination
of the lesionsindicated acantholysis and
dyskeratosis primarily in the granular layer.The
patient's serum contained antibodies to intercellular
substance.Direct immunofluorescence microscopy of a
lesion demonstratedimmunoglobulin deposition in the
intercellular areas. Treatment withoral prednisone
produced rapid resolution of the lesions. Patients in whom eruptive seborrheic keratoses (Leser-Trelat
sign) develop shouldhave histological examination
of their lesions to rule out the diagnosisof
pemphigus foliaceus.
===========================================================
35.) Eruptive seborrheic keratoses in a young woman
with acromegaly.
===========================================================
SO - J Am Acad Dermatol 1990 Nov;23(5 Pt
2):991-4
AU - Kilmer SL; Berman B; Morhenn VB
PT - JOURNAL ARTICLE
AB - The sign
of Leser-Trelat, or eruptive seborrheic keratoses, is purported to be a cutaneous marker for many
underlying malignancies.Elevation in levels of
growth factors has been postulated to be the
stimulus for the sudden eruption of multiple new
seborrheic keratoses.In support of this hypothesis
we present a case of eruptive seborrheickeratoses
in a young woman with acromegaly and elevated levels of
growthhormone.
===========================================================
36.) Seborrheic keratosis and papillomatosis:
markers of breastadenocarcinoma.
===========================================================
SO - Cutis 1983 Aug;32(2):161-2
AU
- Friedman-Birnbaum R; Haim S
PT - JOURNAL
ARTICLEAB -
Seborrheic keratosis
(Leser-Trelat sign) and extensive florid
papillomatosis of the skin and the mucous membranes of
the nose, mouth,throat, and external genitalia were
associated with adenocarcinoma ofthe breast in a
61-year-old woman.
===========================================================
37.) A case of hepatocellular carcinoma with the
sign of Leser-Trelat: apossible role of a cutaneous
marker for internal malignancy.
===========================================================
Jpn J Med 1991 Jan-Feb;30(1):53-6 Related Articles,
Books, LinkOut
Tajima H, Mitsuoka
S, Ohtsuka E, Nakamura Y, Nakayama T, Satoh Y, Shima
M, Nakata K, Kusumoto Y, Koji T, et al
First Department
of Internal Medicine, Nagasaki University School of
Medicine, Japan.
A rare case of
hepatocellular carcinoma who developed the complication of the sign of Leser-Trelat is reported. The
patient, a 57-year-oldmale, visited our hospital
with complaints of generalized malaise andanorexia.
A diagnosis of hepatocellular carcinoma was made based
onelevated alpha-fetoprotein measurement,
ultrasonography, and hepaticarteriography findings.
Chest x-ray film suggested pulmonary metastasesof
hepatocellular carcinoma. Thereafter, complications of
the seborrheickeratosis developed in the trunk and
the skin lesion was diagnosed asthe sign of
Leser-Trelat associated with hepatocellular carcinoma.
Thepatient died of pneumonia 9 months after
development of the sign ofLeser-Trelat.
===========================================================
38.) the relation between seborrheic keratoses and
malignant solidtumours. A case-control study.
===========================================================
Acta Derm Venereol 1991;71(2):166-9 Related
Articles, Books
Grob JJ, Rava MC,
Gouvernet J, Fuentes P, Piana L, Gamerre M, Sarles JC,
Bonerandi JJ
Service de Dermatologie, Hopital Ste Marguerite,
Marseille, France.
In order to
establish whether or not here is an association between cancer and intense growth of seborrheic keratosis,
the so-calledLeser-Trelat sign, we conducted a case
control study in which the numberand features of
seborrheic keratosis in 82 patients with recent solid tumours, were compared with 82 age- and sex-matched
controls. Neithernumbers nor features of seborrheic
keratosis differed significantly inpatients and
controls. Eruptive seborrheic keratosis was noted in
onlyone patient and one control.
This study showed
that solid malignanciesare not generally associated
with an increase in the number or size ofseborrheic
keratosis lesions, thus suggesting that they are not
controlled by a hypothetical secretion of growth factors
by tumours. Ourresults suggest that Leser-Trelat is
either a coincidence, or at most avery rare sign of
unusual types of cancer. We also showed that multiple cherry angiomas, previously reported to be a
paraneoplastic sign, arenot regularly associated
with solid tumours.
===========================================================
39.) [Useful cutaneous markers of internal
malignancy in the earlystage].
===========================================================
Gan To Kagaku Ryoho 1988 Apr;15(4 Pt 2-3):1564-8
Related Articles, Books
Mori S
Dept. of Dermatology, Gifu University School of
Medicine.
Numerous skin
changes are correlated with internal malignancy. These skin changes are collectively called dermadromes of
internal malignancyor syndroma dermato-tumorale.
The skin markers of internal malignancycan be
classified into
1) skin metastasis,
2) paraneoplastic
dermatoses,
3) cutaneous manifestations of the
systemic carcinogenic disease processand
4)
cancer-malformation syndrome.
For diagnosis of the early
stage ofinternal malignancy, paraneoplastic
dermatoses are the most importantamong other skin
changes. Above all, dermatomyositis, figurate
erythemas, erythroderma and a number of bullous
dermatoses (e.g.,bullous pemphigoid, pemphigus
vulgaris and dermatitis herpetiformis,Sweet'
syndrome, pruritus, prurigo, acanthosis nigricans,
Leser-Trelatsign, alopecia mucinosa, acquired
ichthyosis, Bazex' syndrome,hypertrichosis aquisita
lanuginosa) are among the paraneoplasticdermatoses.
A total of 405 cases of syndroma dermato-tumorale except cases of skin metastasis were reported for recent 7
years (1980-1986)only in the dermatological field
in Japan. Among them, cases ofparaneoplastic
dermatoses number 354 accounting for the majority.
Finally, brief consideration is given to the
relationship between theabove mentioned skin
manifestations and internal malignancy.
===========================================================
40.) [Gastrointestinal carcinoma with skin diseases
from the standpointof surgery].
===========================================================
Gan To Kagaku Ryoho 1988 Apr;15(4 Pt 2-3):1560-3
Related Articles, Books
Nishidoi H, Koga S, Kanbe N
1st Dept. of Surgery, Tottori University School of
Medicine.
We encountered 21
patients with gastrointestinal carcinoma accompanied
with skin diseases such as acanthosis nigricans,
dermatomyositis,pemphigoid, erythrodermia,
ichthyosis vulgaris, herpes zoster,Leser-Trelat's
sign, Recklinghausen's disease and Gardner's syndrome.
Wehave discussed such cases from the standpoint of
surgery. There were 16cases (76%) with gastric
carcinoma, which were almost in the faradvanced
stage. Carcinomas of the other patients were seen in the esophagus, liver, pancreas, small intestine and
rectum. Although skinlesions appeared before the
onset of gastrointestinal symptoms in almostall
cases, detection of carcinomas was very difficult until
the symptomsemerged. In 6 of 21 patients (29%),
carcinomas were detected by onlyskin manifestation,
and they proved to be gastric cancer in all cases.
Although the relationship of gastrointestinal carcinoma
and skindiseases was unclear, we presented a 70-year-old
woman with acanthosisnigricans accompanied with
gastric cancer, whose skin manifestation wasreduced
by the therapy for gastric cancer. Therefore, some of
these skinmanifestation may be a symptom of the
biological characteristics of thegastrointestinal
carcinoma.
===========================================================
41.) [Leser-Trelat sign in adenocarcinoma of the
sigmoid colon--a rareclinical picture].
===========================================================
Z Hautkr 1987 Jun 1;62(11):875-6 Related Articles,
Books
Hodak E, Halevy S, Ingber A, Engelstein D,
Sandbank M
We report on a 75-year-old
man showing the very rare association of
Leser-Trelat's sign and adenocarcinoma of the sigmoid
colon. Our case isthe second one reported so far.
===========================================================
42.) [Acanthosis nigricans maligna and Leser-Trelat
sign in doublemalignancy of the breast and stomach].
===========================================================
Z Hautkr 1987 Mar 1;62(5):344-66 Related Articles,
Books
Stieler W, Plewig G
A female patient
with primary cancer of the breast and the stomach
developed acanthosis nigricans maligna and
Leser-Trelat's sign.Acanthosis nigricans maligna is
a well-known cutaneous marker ofinternal malignancy.
It may be intensified by radiotherapy. A variant is
called florid cutaneous papillomatosis. Leser-Trelat's
sign is a rarecutaneous marker of internal
neoplasms. According to the literature, wepresent
46 patients showing Leser-Trelat's sign. Neither Leser
norTrelat described this sign.
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43.) Beitrage Zur Fruhdiagnose des darmcarcinoms (Hereditasverhaltnisse und Hautveranderungen) hollander E
Dtsch Med
Woschenschr 1900;26:483-5
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DATA-MEDICOS/DERMAGIC-EXPRESS No 2-(92)
05/03/2.000 DR. JOSE LAPENTA R.
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