EDITORIAL
ESPAÑOL
================
Hola Amigos DERMAGICOS, iniciando los temas del año 2.001, seleccione este
interesante titulo para una enfermedad descrita por DARIER en el año de 1.916
bajo el nombre de Eritema Anular Centrifugo. Clasificado dentro del capitulo de
los ERITEMAS FIGURADOS, donde algunos lo consideran de causa desconocida y otros
una manifestación cutánea de malignidad interna, pero yo pienso que esto va mas
alla de estos conceptos.
Esta enfermedad o SIGNO dermatológico tiene varias formas de presentación: Una
forma profunda y otra superficial que incluye a su vez varios subtipos: Con
vesicula
cion, Prurito, y descamación. Las lesiones pueden ser o no migratorias.
Puede presentarse en adultos y niños. Muchas veces desaparece después de
identificada y tratada la causa.
Si analizamos con detalle estas 100 referencias bibliográficas podemos sacar
las siguientes conclusiones:
Entidad Clínica:
Eritema figurado
1.) Tipos:
a.) Profundo.
b.) Superficial: subtipos:
Vesiculoso y escamoso con o sin
prurito
2.) Etiología:
a.) Se sospecha de una respuesta de hipersensibilidad a
antígenos desconocidos.
3.) Asociaciones:
a.) Comidas: Tomates, queso azul.
b.) Drogas: Cimetidina, Antimalaricos, Penicilina,
Salicilatos, Estrógenos, Progesterona, K vitamin
a, piroxicam,
ampicilina y otros
c.) Agentes vivos:
Molusco contagioso, Epstein
Barr
virus, ascariasis, yersinia, Infecciones
estreptocócicas,
Mycobaterium tuberculosis,
Dermatofitos, Cándida albicans.
d.) Enfermedades del colágeno:
Lupus, Síndrome de Sjogren, CREST
síndrome.
e.) Enfermedades ampollares:
Penfigoide ampollar, pénfigo,
Enfermedad por IgA lineal.
f.) Enfermedades escamosas:
Psoriasis.
g.) Enfermedades granulomatosas:
Sarcoidosis, Tuberculosis.
h.) Enfermedades malignas:
Mieloma múltiple, Leucemia,
Enfermedad de Hodgkin.
i.) Enfermedades endocrinas:
Tiroiditis de Hashimoto, enfermedad
de Graves.
j.) Enfermedades eosinofilicas:
Síndrome hipereosinofilico.
k.) Misceláneos:
Idiopático, familiar.
Si unificamos TODOS estos datos entonces lo podríamos considerar como un
MARCADOR CUTÁNEO O SIGNO DERMATOLÓGICO asociado a todas estas entidades. De modo
que si les presenta esta enfermedad en su practica diaria. Piensen en esta
clasificación la cual les ayudara a identificar mejor la causa y pedir los
respectivos exámenes de laboratorio para reconocer verdaderamente que lo
provoco.
En las referencias los hechos ...
Saludos a todos.
Dr. José
Lapenta R.
EDITORIAL ENGLISH
==================
A classification for the Erythema Annulare Centrifugum
Hello DERMAGICS friends, beginning the topics of the year 2.001, select this
interesting one I title for an illness described by DARIER in the year of 1.916
under the name of Erythema Annulare Centrifugum. Classified inside the GYRATE
ERYTHEMAS, where some consider it of unknown etiology and other caused by
cutaneous manifestation of internal malignancy, but I think that this goes but
there of these concepts.
This illness or dermatologico SIGN have several presentation forms: A deep
form and another superficial one that it includes several subtypes: With
vesiculation, Pruritus, and scaling. The lesions can be or not migratory. It can
be presented in adults and children. Many times desapear after identified and
treated the cause.
If we analyze with detail these 100 bibliographical references we can reach
the following conclusions;
Clinical Entity:
Gyrate Erythema
1.) types:
a.) Deep.
b.) Superficial: Subtypes:
Bullous and scaly with or without
pruritus
2.) Etiology:
A hypersensitivity response to unrecognized antigens is
suspected.
3.) associations:
a.) Foods: Tomatoes, blue cheese.
b.) Drugs: Cimetidin, Antimalarials, Penicillin,
Salicylates, Estrogen-Progesteron, K vitamin, piroxicam, ampicillin
and others
c.) Alive Agents:
Molluscum Contagiosum, Epstein Barr
virus, ascariasis, yersiniosis, Streptococcal infections,
Mycobateriun tuberculosis,
Dermatophytes, Cándida albicans.
d.) Colagen diseases:
Lupus, Sjogren syndrome, CREST
syndrome.
e.) Bullous disease:
Bullous Pemphigoid, lineal IgA
disease, pemphigus.
f.) Scaly diseasse:
Psoriasis
g.) Granulomatous diseases:
Sarcoidosis, Tuberculosis
h.) mailgnant diseases:
Myeloma, Leukemia, Hodgkin's
disease,
i.) Endocrine Diseases:
Tiroiditis of Hashimoto, Grave's
disease.
j.) Eosinophilic diseases:
Hypereosinophilic syndrome.
k.) Miscelaneous:
Idiopatic, Familial
If we unify ALL these data then we could consider it as a CUTANEOUS MARKER OR
DERMATOLOGIC SIGN associated to all these entities. So that if it presents you
this illness in your daily practice, think on this classification which helped
you to identify the cause better and to request the respective laboratory exams
to truly recognize that I provoke it.
In the references the facts...
Greetings to all !!!
Dr. José Lapenta R.
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REFERENCIAS
BIBLIOGRÁFICAS / BIBLIOGRAPHICAL REFERENCES
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1.) Gyrate erythema.
2.) [Erythema annulare centrifugum Darier].
3.) Recurrent acute appendicitis with erythema annulare centrifugum.
4.) Erythema annulare centrifugum, angio-oedema in lupus vulgaris.
5.) Erythema annulare centrifugum. A case due to tuberculosis.
6.) [Erythema annulare centrifugum of the legs symptomatic of prostate
adenocarcinoma; a specific paraneoplastic syndrome]?
7.) Erythema annulare centrifugum and Hodgkin's disease: association with
disease activity.
8.) On erythema annulare centrifugum-type of psoriasis.
9.) Annular psoriasiform eruption with lymphocytic
infiltration of the epidermis: a variant of acute psoriasis?
10.) Psoriasis: odd varieties in the adult.
11.) [Localized form of psoriasis of the erythema annulare centrifugum type
with pustulation]
12.) [Psoriasis and pustular psoriasis of the erythema annulare centrifugum
type (3 cases)].
13.) Erythema annulare centrifugum induced by molluscum contagiosum.
14.) Erythema annulare centrifugum and molluscum contagiosum.
15.) [Hypereosinophilic syndrome. Cutaneous picture of "erythema annulare
centrifugum"--comparison with ultrastructural study].
16.) [Hypereosinophilic syndrome. Centrifugal annular erythema as an initial
manifestation].
17.) Erythema annulare centrifugum as the presenting sign of the
hypereosinophilic syndrome: observations on therapy.
18.) [Erythema annulare centrifugum as a symptom in acute myeloid leukemia].
19.) Annular erythemas in infants associated with autoimmune disorders in
their mothers. Report on three cases.
20.) Ampicillin induced erythema annulare centrifugum.
21.) [Specific leukemic infiltration with the appearance of erythema annulare
centrifugum (Darier) in chronic lymphadenosis].
22.) Unusual cutaneous associations of a malignant carcinoid tumour of the
bronchus--erythema annulare centrifugum and white banding of the toe nails.
23.) [The bullous variant of erythema annulare centrifugum Darier in Candida
albicans infections].
24.) [Migrant eruptions in lupus erythematosus. Apropos of a case of lupus
erythematosis gyratus repens].
25.) Erythema annulare centrifugum coincident with Epstein-Barr virus
infection in an infant.
26.) Erythema annulare centrifugum and relapsing polychondritis.
27.) Vulvar disease in children: a clinical audit of 130 cases.
28.) Amitriptyline-induced erythema annulare centrifugum.
29.) Drugs causing fixed eruptions: a study of 450 cases.
30.) Erythema annulare centrifugum in a patient with polyglandular autoimmune
disease type 1.
31.) Recurrent ringed lesion of the sole: erythema annulare centrifugum.
32.) Erythema annulare centrifugum associated with pregnancy.
33.) [Annular erythema in childhood--a new eosinophilic dermatosis].
34.) Erythema annulare centrifugum and intestinal Candida albicans infection--coincidence
or connection?
35.) Dermacase. Erythema annulare centrifugum.
36.) Psoriasis: changing clinical patterns.
37.) Erythema annulare centrifugum and Escherichia coli urinary infection.
38.) Sarcoidosis presenting as erythema annulare centrifugum.
39.) [Recurrent annular erythema--cutaneous manifestation of Sjogren syndrome
with anti SS-A (Ro) and anti SS-B (La) antibodies].
40.) Non-small-cell lung cancer with multiple paraneoplastic syndromes.
41.) [Darier's erythema annulare centrifugum of neonatal onset with a 15 years'
follow-up. Efficacy of interferon and role of cytokines].
42.) Erythema annulare centrifugum unresponsive to immunosuppressive therapy.
43.) Annular vasculitis associated with pregnancy.
44.) Inflammatory carcinoma masquerading as erythema annulare centrifugum.
45.) [Darier's erythema annulare centrifugum and primary Vaquez polycythemia]
46.) Recurrent annular erythema with anti-SSA/Ro and anti-SSB/La antibodies
localized on palms and fingers in an elderly man.
47.) Clinical and immunological analysis of annular erythema associated with
Sjogren syndrome.
48.) Clinical, serological and immunogenetic features of Japanese
anti-Ro/SS-A-positive patients with annular erythema.
49.) Persistent annular erythema of infancy.
50.) HLA antigens in anti-Ro(SS-A)-positive patients with recurrent annular
erythema.
51.) Urticated annular erythema: a new manifestation of Sjogren's syndrome.
52.) Recurrent annular erythema associated with anti-SS-
53.) Erythema annulare centrifugum associated with gold sodium thiomalate
therapy.
54.) Annular erythema. A comparative study of Sjogren syndrome with subacute
cutaneous lupus erythematosus.
55.) Annular erythema associated with Sjogren's syndrome: a variant of
systemic lupus erythematosus [see comments]
56.) Lymphocyte response to staphylococcal enterotoxin B in patients with
annular erythema associated with Sjogren syndrome.
57.) ICAM-1 and LFA-1 expressions in the lesional skin of annular erythema
associated with Sjogren syndrome.
58.) Annular erythema associated with primary Sjogren syndrome: analysis of T
cell subsets in cutaneous infiltrates [see comments]
59.) Annular erythema in identical twins.
60.) Annular erythema: a possible association with primary Sjogren's syndrome.
61.) Neonatal lupus syndrome and microtubular structure.
62.) Erythema annulare of infancy.
63.) An annular erythema of infancy.
64.)Reactive annular erythema after intramuscular vitamin K.
65.) Annular erythema of infancy.
66.) [Erythema annulare centrifugum revealing linear IgA dermatitis of
childhood]
67.) Erythema annulare centrifugum: an unusual case due to hydroxychloroquine
sulfate.
68.) 'Persistent' annular erythema of infancy.
69.) Erythema annulare centrifugum associated with ascariasis.
70.) Annular erythema of infancy.
71.) Annular erythema as an unusual manifestation of chronic disseminated
lupus erythematosus.
72.) Multiple annular erythema [letter]
73.) Reactive erythemas: erythema annulare centrifugum and erythema gyratum
repens.
74.) [Squamous erythema annulare centrifugum]
75.) Annular erythema associated with Sjogren's syndrome [letter; comment]
76.) An intensive care unit nurse with a recurring annular lesion. Erythema
annulare centrifugum (EAC).
77.) Erythema annular centrifugum in Q fever.
78.) Erythema annulare centrifugum caused by hydrochlorothiazide-induced
interstitial nephritis.
79.) [Erythema annulare centrifugum disclosing hyperthyroidism]
80.) Eruption resembling erythema annulare centrifugum due to thiacetazone [letter]
81.) [Erythema annulare centrifugum caused by aldactone]
82.) [On the physiopathology of erythema annulare centrifugum]
83.) Erythema annulare centrifugum associated with liver disease.
84.) [Erythema annulare centrifugum and Hashimoto's thyroiditis]
85.) Erythema annulare centrifugum associated with piroxicam [letter]
86.) Annular erythema with histologic features of leukocytoclastic vasculitis
in ulcerative colitis.
87.) Erythema annulare centrifugum and malignant histiocytosis--report of a
case.
88.) Pityrosporum infection in an infant with lesions resembling erythema
annulare centrifugum.
89.) Erythema annulare centrifugum: a review of 24 cases with special
reference to its association with underlying disease.
90.) [Pemphigoid with recurrence of the centrifugal-development bullous
annular erythema type]
91.) [Bullous pemphigoid with an erythema annulare centrifugum appearance and
a bullous border]
92.) [Erythema annulare centrifugum and antinuclear antibodies]
93.) Erythema annulare centrifugum. A case due to tuberculosis.
94.) Erythema annulare centrifugum and Graves' disease [letter]
95.) Cimetidine-induced erythema annulare centrifugum: no cross-sensitivity
with ranitidine.
96.) [Nosologic problems posed by a case of desquamative erythema annulare
centrifugum]].
97.) [Erythema annulare centrifugum Darier as a reaction form in diseases of
the reticulo-histiocyte system].
98.) [Erythema annulare centrifugum of Darier, squamous variety].
99.) [Erythema annulare centrifugum with loco-regional recurrences during the
course of tuberculous coxitis. Focal reaction to tuberculin].
100.) The Gyrate Erythemas
101.) Erythema annulare centrifugum: case due to hypersensivite to blue cheese
penicillium.
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1.) Gyrate erythema.
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Dermatol Clin 1985 Jan;3(1):129-39
White JW Jr
The gyrate erythemas consist of a nonspecific group (often called erythema
annulare centrifugum) for which the cause is usually unknown, and three specific
types (erythema marginatum rheumaticum, erythema chronicum migrans [Lyme disease],
and erythema gyratum repens). The first specific type, erythema marginatum
rheumaticum, has become extremely rare with the decline of its associated
disease, rheumatic fever. The second specific type, erythema chronicum migrans,
is caused by a spirochete transmitted by the I. ricinus complex of ticks. The
third specific type, erythema gyratum repens, is uncommon, morphologically
distinctive, and an indicator of serious disease, usually internal malignancy,
in almost every instance.
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2.) [Erythema annulare centrifugum Darier].
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Hautarzt 1979 Dec;30(12):673-5 Related Articles, Books, LinkOut
[Article in German]
Baurle G
The symptoms of erythema anulare centrifugum Darier are demonstrated in a 60-year-old
patient. A paraneoplastic syndrome was sufficiently ruled out. The skin lesions
quickly healed during treatment of an urinary tract infection.
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3.) Recurrent acute appendicitis with erythema annulare centrifugum.
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Arch Intern Med 1984 Oct;144(10):2090-2 Related Articles, Books, LinkOut
Sack DM, Carle G, Shama SK
Erythema annulare centrifugum (EAC), a chronic figurate eruption, occurred in
a 28-year-old male physician several months following the onset of recurrent
abdominal pain. Two months after the manifestation of EAC, another episode of
abdominal pain culminated in appendectomy for perforated appendicitis. During
his convalescence, the skin lesions faded and did not reappear. We propose that
recurrent appendiceal inflammation caused both the episodic pain and the skin
eruptions. Additionally EAC may be a sign of chronic infection, internal
malignancy, or food allergy. Although truly chronic appendicitis is a disputed
entity, recurrent, spontaneously resolving episodes of appendicitis occasionally
do precede surgical appendicitis. The presence of EAC in a patient having
recurrent abdominal pain should discourage a precipitant diagnosis of functional
illness and prompt further investigation.
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4.) Erythema annulare centrifugum, angio-oedema in lupus vulgaris.
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JPMA J Pak Med Assoc 1984 Sep;34(9):276-9
Shabbir SG, Hassan M, Kazmi SA, Jahangir M
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5.) Erythema annulare centrifugum. A case due to tuberculosis.
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Int J Dermatol 1982 Nov;21(9):538-9 Related Articles, Books, LinkOut
Burkhart CG
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6.) [Erythema annulare centrifugum of the legs symptomatic of prostate
adenocarcinoma; a specific paraneoplastic syndrome]?
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Ann Dermatol Venereol 1979 Oct;106(10):789-92 Related Articles, Books, LinkOut
[Article in French]
Dupre A, Carrere A, Bonafe JL, Viraben R, Christol B, Lassere J
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7.) Erythema annulare centrifugum and Hodgkin's disease: association with
disease activity.
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Arch Intern Med 1979 Apr;139(4):486-7 Related Articles, Books, LinkOut
Leimert JT, Corder MP, Skibba CA, Gingrich RD
The skin lesions of erythema annulare centrifugum developed in a 58-year-old
woman who had Hodgkin's disease. Response of the neoplasm to vinblastine sulfate
was accompanied by disappearance of the skin lesions. When therapy was
discontinued, both disorders recurred, and both responded to reinstitution of
vinblastine therapy. To our knowledge, this case is the first reported
association of erythema annulare centrifugum and Hodgkin's disease. The
cutaneous manifestation in this patient were a nonneoplastic concomitant of her
neoplastic disorder.
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8.) On erythema annulare centrifugum-type of psoriasis.
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Acta Derm Venereol Suppl (Stockh) 1979;59
Rajka G, Thune PO
A case of EAC type psoriasis is reported. Routine and immunologic
investigations were negative. HLA-B8 was found by typing. Some therapeutic
benefit was achieved by combination of retinoid (Ro-10-9359) plus PUVA.
According to a review of the literature half of the cases are unconnected to
classical psoriasis, whereas the other half is connected and mostly of (periodic)
pustular character. The necessity of clinical research in this intermediate type
between psoriasis vulgaris and pustulosa is emphasized.
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9.) Annular psoriasiform eruption with lymphocytic
infiltration of the epidermis: a variant of acute psoriasis?
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SO - Dermatology 1992;185(2):156-9
AU - Terunuma A; Takahashi K; Sakakibara A; Aiba S; Tagami H
PT - JOURNAL ARTICLE
AB - Disseminated annular psoriasiform lesions developed over a period of 2
months in a 48-year-old man with no preceding psoriatic history of drug intake,
being accompanied by general dullness and arthralgia. Etretinate was effective
for both skin eruption and arthralgia; only the latter recurred on its cessation
5 months later. However, histologic features examined by serial sections totally
lacked those of pustular psoriasis; there were no neutrophils in the epidermis
where massive T lymphocyte infiltration existed instead, in a fashion similar to
that of early psoriatic lesions. We differentiated this peculiar annular
psoriasiform eruption from the annular erythematous lesions noted in pityriasis
rosea, erythema annulare centrifugum, subacute cutaneous lupus erythematosus,
annular erythema associated with Sjogren's syndrome and erythema chronicum
migrans. It is our speculation that this dermatosis represents a variant of
acute psoriasis, rather than annular pustular psoriasis. The histopathologic and
immunohistologic findings suggest ongoing cellular immune responses in these
lesions where some unknown inhibitory mechanisms might be operative against
further production of neutrophil chemotactic factors that usually takes place in
psoriatic lesions.
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10.) Psoriasis: odd varieties in the adult.
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Acta Derm Venereol Suppl (Stockh) 1979;87:90-4
Kerl H, Pachinger W
Occasionally we observe particular varieties of psoriasis and in rare cases
transitional features with other diseases, which pose problems concerning the
differential diagnosis and the nosological classification. This communication
deals with the following clinical and histological aspects of psoriasis: 1)
Sebopsoriasis. Relationship of psoriasis to pityriasis rubra pilaris. 2)
Erythema annulare centrifugum type of psoriasis. 3) Is subcorneal pustular
dermatosis an expression of pustular psoriasis? 4) Salient histopathological
criteria for the diagnosis of the different atypical forms of psoriasis. 5)
Presentation of an unusal case with striated and retiform verrucous psoriasis-like
eruptions, which show a relationship to parakeratosis variegata.
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11.) [Localized form of psoriasis of the erythema annulare centrifugum type
with pustulation]
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SO - Hautarzt 1984 Jan;35(1):53-5
AU - Zala L; Hunziker T
PT - JOURNAL ARTICLE
AB - We report two cases of localized psoriasis of the erythema anulare
centrifugum-type with pustulation. Problems of nosological classification and
histological differentiation are discussed.
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12.) [Psoriasis and pustular psoriasis of the erythema annulare centrifugum
type (3 cases)].
Bull Soc Fr Dermatol Syphiligr 1966 Jul-Aug;73(4):356-8
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[Article in French]
Degos R, Civatte J, Arrouy M
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13.) Erythema annulare centrifugum induced by molluscum contagiosum.
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Br J Dermatol 1993 Nov;129(5):646-7
Furue M, Akasu R, Ohtake N, Tamaki K
Publication Types:
Letter
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14.) Erythema annulare centrifugum and molluscum contagiosum.
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Arch Dermatol 1978 Dec;114(12):1853
Vasily DB, Bhatia SG
Publication Types:
Letter
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15.) [Hypereosinophilic syndrome. Cutaneous picture of "erythema annulare
centrifugum"--comparison with ultrastructural study].
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Med Cutan Ibero Lat Am 1988;16(4):299-304
[Article in Portugese]
Calux MJ, Valente NY, Pires MC, Albertoni Neto DR
Hospital do Servidor Publico Estadual de Sao Paulo.
The authors present the third case in the literature of hypereosinophilic
syndrome with "erythema annulare centrifugum" like lesions. Cutaneous
manifestations were the first sign of the disease. Laboratory investigation
including ultrastructural study of cutaneous lesions. This kind of investigation
has been done before in only one instance. Clinical and laboratory features of
the case are fully discussed taking into account literature findings.
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16.) [Hypereosinophilic syndrome. Centrifugal annular erythema as an initial
manifestation].
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Med Cutan Ibero Lat Am 1978;6(5-6):267-72
[Article in Spanish]
Woscoff A, Dancziger E, Zamparo DI
Several closely related conditions make up the idopathic hypereosinophilic
syndrome. This syndrome is characterized by persistent and prolonged
eosinophilia. The most frequent lesions are in the hematologic, neurologic and
gastrointestinal systems. A case is reported in which the initial complaint was
an erythema annulare centrifugum.
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17.) Erythema annulare centrifugum as the presenting sign of the
hypereosinophilic syndrome: observations on therapy.
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SO - Cutis 1985 Jan;35(1):53-5
AU - Shelley WB; Shelley ED
PT - JOURNAL ARTICLE
AB - A 79-year-old man with severe generalized pruritus and erythema annulare
centrifugum as manifestations of his idiopathic hypereosinophilic syndrome
slowly responded to long-term therapy with ketoconazole and dapsone. The skin
lesions cleared within one month but the pruritus and eosinophilia required
seven full months of therapy.
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18.) [Erythema annulare centrifugum as a symptom in acute myeloid leukemia].
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Z Hautkr 1977 Feb 1;52(3):77-80
[Article in German]
Bonniger F, Happle R
Erythema annulare centrifugum occurred in a 68 year-old women suffering from
acute myeloid leukemia. A "paraneoplastic" origin of the skin disease was most
probable in this case.
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19.) Annular erythemas in infants associated with autoimmune disorders in
their mothers. Report on three cases.
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Dermatologica 1977;154(2):115-27
Hammar H, Ronnerfalt L
Three infant boys with a centrifugal annular erythema mainly consistent with
erythema annulare centrifugum, developing a few weeks after birth, are described.
The lesions disappeared before the age of 6 months, without atrophy, and during
this period the infants were otherwise healthy. This group is considered to
belong to one of three types of reactivity in infants associated with or
expressed as a connective tissue disease, especially lupus erythematosus, in the
mother and child or in either. In type 1, signs and symptoms of systemic lupus
erythematosus are or will be present in the mother and the child displays
discoid lupus erythematosus lesions at birth or soon after. In type 2, the
mother has the same signs and symptoms as in type 1 but the child develops a
centrifugal annular erythema 3-6 weeks after birth. In type 3, discoid lupus
erythematosus is present at an early stage in the infant, while the mother is
healthy. This type may represent an early onset of lupus erythematosus in the
infants.
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20.) Ampicillin induced erythema annulare centrifugum.
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J Indian Med Assoc 1975 Dec 1;65(11):307-8
Gupta HL, Sapra SM
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21.) [Specific leukemic infiltration with the appearance of erythema annulare
centrifugum (Darier) in chronic lymphadenosis].
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Hautkr 1975 Nov 15;50(22):930-7
[Article in German]
Diem E
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22.) Unusual cutaneous associations of a malignant carcinoid tumour of the
bronchus--erythema annulare centrifugum and white banding of the toe nails.
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Br J Dermatol 1975 Sep;93(3):341-5
Everall JD, Dowd PM, Ardalan B
The case history of a patient who presented with erythema annulare centrifugum
and white banding of the toe nails is recorded. On investigation for an
underlying malignancy the patient was found to have an opacity in the lower lobe
of the right lung. Subsequently lobectomy was performed and histology of the
operative specimen revealed a malignant carcinoid tumour of the bronchus.
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23.) [The bullous variant of erythema annulare centrifugum Darier in Candida
albicans infections].
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Hautarzt 1975 Sep;26(9):466-70
[Article in German]
Kind R
A 15-year old male patient with Down-Syndrome suffering from a unusual
vesicular type of erythema annular centrifugum Darier and a concurrent
intestinal infection with candida albicans is described. Histology,
immunhistological assay, and clinical observation allowed to differentiate
Erythema annulare centrifugum from erythema exsudativum multiforme as well as
dermatitis herpetiformis. On the basis of immunological findings and the
clinical course, a hypersensitivity to candida albicans like a so-called "id-reaction"
is assumed to be the main etiological factor in this case.
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24.) [Migrant eruptions in lupus erythematosus. Apropos of a case of lupus
erythematosis gyratus repens].
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Ann Dermatol Syphiligr (Paris) 1975;102(5-6):481-9
[Article in French]
Hewitt J, Benveniste M, Kaufmann P, Lessana-Leibowitch M
Rare cases of migrant circinated eruptions occurring during the course of
lupus erythematosus have been published so far. They have been classified in two
categories: 1) supposed toxicodermias due to antimalarials; 2) real cases of
erythema annulare centrifugum, mostly inaugurating the L. E. In an exceptional
case, a migrating eruption looking like an erythema annulare with a complicated
pattern on the trunk, neck and limbs, took place between two rashes of typical
L.E. The exact nature of this eruption, clinically and histologically atypical,
and its relation with the L.E. itself, have been discussed.
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25.) Erythema annulare centrifugum coincident with Epstein-Barr virus
infection in an infant.
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Acta Paediatr Scand 1974 Sep;63(5):788-92
Hammar H
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26.) Erythema annulare centrifugum and relapsing polychondritis.
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Ann Dermatol Venereol 2000 Aug-Sep;127(8-9):735-9
Ingen-Housz S, Venutolo E, Pinquier L, Cavelier-Balloy B, Dubertret L, Flageul
B
Service de Dermatologie 1, Hopital Saint-Louis, 1, avenue Claude-Vellefaux,
75475 Paris Cedex 10.
[Medline record in process]
BACKGROUND: Relapsing polychondritis is a rare systemic disease. Skin
involvement occurs in 20 to 50 % of cases. Cutaneous signs are most often
related to a leukocytoclastic vasculitis. Association of relapsing
polychondritis with neutrophilic dermatosis have also been reported. We report
the first case of an erythema annulare centrifugum-like dermatosis associated
with relapsing polychondritis, with a two years delay between both conditions.
CASE REPORT: A 74 year-old man was seen for papulo-erythematous centrifugal
annular lesions that appeared 18 months earlier in a context of bad general
conditions. Biological tests were normal. Several skin biopsies were performed,
showing at the beginning features of drug reaction and then of lupus-lichen.
Treatment with hydroxychloroquine, topical corticosteroids, dapsone and
thalidomide were unsuccessful. In the following months, the patient developed
fever and relapsing bronchitis. Suddenly, a chondritis of the ears appeared,
leading to the diagnosis of relapsing polychondritis. All the cutaneous,
chondritic and respiratory signs disappeared with oral steroid therapy. Two
years after the diagnosis of relapsing polychondritis the patient developed
refractory anemia. DISCUSSION: Cutaneous signs of relapsing polychondritis are
frequent and may occur several months or years before the chondritis. They are
polymorphous, but to the best of our knowledge, a clinical aspect of erythema
annulare centrifugum has never been described. Our observation recalls the
sometimes long delay between the cutaneous and the chondritic signs of relapsing
polychondritis and the high frequency of dysmyelopoiesis in relapsing
polychondritis with cutaneous involvement.
============================================================
27.) Vulvar disease in children: a clinical audit of 130 cases.
============================================================
Pediatr Dermatol 2000 Jan-Feb;17(1):1-6
Fischer G, Rogers M
Department of Dermatology, Royal Alexandra Hospital for Children, Westmead,
Australia.
We evaluated 130 prepubertal girls presenting with a vulvar complaint to
determine the spectrum and frequency of conditions seen in this age group. Of
the patients, 41 (33%) had atopic or irritant dermatitis, 23 (18%) had lichen
sclerosus, 21 (17%) had psoriasis, 15 (12%) had vulvar lesions, most often
hemangiomas and nevi, and 13 (10%) had streptococcal vulvovaginitis. Diagnoses
less frequently seen were staphylococcal folliculitis (four patients), labial
fusion (three patients), genital warts (two patients), molluscum contagiosum of
the vulva only (one patient), vulvar bullous pemphigoid (two patients), scabies
nodules (one patient), erythema annulare centrifugum (one patient), tinea (two
patients), and vitiligo (one patient). We also encountered vulvar presentations
of systemic diseases (varicella, staphylococcal scalded skin syndrome, and
Henoch-Schonlein purpura, all one patient each). We did not see candidal
vulvovaginitis in this age group nor did we encounter bacterial infection with
pathogens other than Staphylococcus aureus and S. pyogenes.
============================================================
28.) Amitriptyline-induced erythema annulare centrifugum.
============================================================
Cutis 1999 Jan;63(1):35-6
Garcia-Doval I, Peteiro C, Toribio J
Department of Dermatology, General Hospital of Galicia, Faculty of Medicine,
Santiago de Compostela, Spain.
A case of amitriptyline-induced superficial erythema annulare centrifugum (EAC)
is reported. Its singular characteristics are prominent epidermal manifestations,
with clinical and histologic vesiculation, associated with vacuolar degeneration
at the dermoepidermal junction; numerous arciform lesions, accompanied by
diffuse erythema on rechallenge; quick change, more rapid than that usually
described for EAC; and a short course, in contrast with the usual chronic
evolution of EAC. To our knowledge, this is the first reported case of EAC
associated with amitriptyline intake.
============================================================
29.) Drugs causing fixed eruptions: a study of 450 cases.
============================================================
Int J Dermatol 1998 Nov;37(11):833-8
Mahboob A, Haroon TS
Department of Dermatology, King Edward Medical College/Mayo Hospital, Lahore,
Pakistan.
BACKGROUND: Drug eruptions are among the most common cutaneous disorders
encountered by the dermatologist. Some drug eruptions, although trivial, may
cause cosmetic embarrassment and fixed drug eruption (FDE) is one of them. The
diagnostic hallmark is its recurrence at previously affected sites. OBJECTIVE:
We evaluated 450 FDE patients to determine the causative drugs. RESULTS: The
ratio of men to women was 1:1.1. The main presentation of FDE was circular
hyperpigmented lesion. Less commonly FDE presented as: nonpigmenting erythema,
urticaria, dermatitis, periorbital or generalized hypermelanosis. Occasionally
FDE mimicked lichen planus, erythema multiforme, Stevens-Johnson syndrome,
paronychia, cheilitis, psoriasis, housewife's dermatitis, melasma, lichen planus
actinicus, discoid lupus erythematosus, erythema annulare centrifugum, pemphigus
vulgaris, chilblains, pityriasis rosea and vulval or perianal hypermelanosis.
Cotrimoxazole was the most common cause of FDE. Other drugs incriminated were
tetracycline, metamizole, phenylbutazone, paracetamol, acetylsalicylic acid,
mefenamic acid, metronidazole, tinidazole, chlormezanone, amoxycillin,
ampicillin, erythromycin, belladonna, griseofulvin, phenobarbitone, diclofenac
sodium, indomethacin, ibuprofen, diflunisal, pyrantel pamoate, clindamycin,
allopurinol, orphenadrine, and albendazole. CONCLUSIONS: Cotrimoxazole was the
most common cause of FDE, whereas FDE with diclofenac sodium, pyrantel pamoate,
clindamycin, and albendazole were reported for the first time. FDE may have
multiform presentations.
============================================================
30.) Erythema annulare centrifugum in a patient with polyglandular autoimmune
disease type 1.
============================================================
Cutis 1998 Nov;62(5):231-2
Garty B
Kipper Institute of Pediatric Immunology, Department of Pediatrics A,
Schneider Children's Medical Center of Israel, Petah Tiqva.
The dermatologic disorders in polyglandular autoimmune disease (PGAD) type 1 (previously
called chronic mucocutaneous candidiasis) are nail dystrophy, vitiligo, and
alopecia. A patient with PGAD and erythema annulare centrifugum (EAC) is
presented. This association has not been reported previously. EAC may be related
to occult or low-grade Candida infection in PGAD.
============================================================
31.) Recurrent ringed lesion of the sole: erythema annulare centrifugum.
============================================================
J Am Podiatr Med Assoc 1998 Mar;88(3):144-5
Lemont H, Garber R, Ortenzi J
Publication Types:
Letter
============================================================
============================================================
32.) Erythema annulare centrifugum associated with pregnancy.
============================================================
Acta Derm Venereol 1998 May;78(3):237-8
Choonhakarn C, Seramethakun P
Publication Types:
Letter
============================================================
============================================================
33.) [Annular erythema in childhood--a new eosinophilic dermatosis].
============================================================
Hautarzt 1998 Feb;49(2):131-4
[Article in German]
Kunz M, Hamm K, Brocker EB, Hamm H
Klinik und Poliklinik fur Haut- und Geschlechtskrankheiten, Universitat
Wurzburg.
Annular erythema of infancy is a rare and little-known entity. Since its
initial description by Peterson and Jarratt in 1981 only 4 further cases have
been reported. We present the first case in the German literature. A 4-year-old
boy developed non-itching erythematous papules on the trunk which evolved into
annular and gyrate erythemas within weeks. The condition showed a relapsing
course with disease-free intervals of several months duration. There were no
general complaints. Laboratory investigations including detailed serological
tests for infectious diseases were normal. Histopathology showed a striking
eosinophilic inflammatory infiltrate predominantly in perivascular areas,
without peripheral blood eosinophilia. The clinical differential diagnosis of
annular erythema of infancy includes erythema annulare centrifugum, while
microscopically one must exclude eosinophilic cellulitis (Wells' syndrome). The
etiology is unknown and there is no effective therapy. In our case, as well as
in all previously published cases, the disease resolved spontaneously. Therefore,
it may be considered benign and self-limited.
============================================================
34.) Erythema annulare centrifugum and intestinal Candida albicans infection--coincidence
or connection?
============================================================
Acta Derm Venereol 1997 Jan;77(1):93-4
Schmid MH, Wollenberg A, Sander CA, Bieber T
Publication Types:
Letter
============================================================
============================================================
35.) Dermacase. Erythema annulare centrifugum.
============================================================
Can Fam Physician 1996 Nov;42:2148, 2151 Related Articles, Books, LinkOut
Enta T
University of Calgary.
============================================================
============================================================
36.) Psoriasis: changing clinical patterns.
============================================================
Australas J Dermatol 1996 May;37 Suppl 1:S27-9 Related Articles, Books,
LinkOut
Rotstein H
Department of Dermatology, St Vincent's Hospital, Melbourne, Victoria,
Australia.
Although psoriasis has been recognized at least since Biblical times new forms,
associations and influences continue to be described in the twentieth century.
New forms include the rupioid erythema annulare centrifugum-like and follicular
patterns. Associations with vitiligo bullous pemphigoid and lupus erythematosus
have been recently described. Endoscopic surgery has increased para umbilical
psoriasis while Sun Smart campaign have reduced photo-aggravated psoriasis.
Infections such as paediatric perianal streptococcal cellulitis and drugs
including angiotensin converting enzyme inhibitors and cytokines exacerbate
psoriasis.
============================================================
37.) Erythema annulare centrifugum and Escherichia coli urinary infection.
============================================================
Lancet 1996 Mar 30;347(9005):897-8
Borbujo J, de Miguel C, Lopez A, de Lucas R, Casado M
Publication Types:
Letter
============================================================
============================================================
38.) Sarcoidosis presenting as erythema annulare centrifugum.
============================================================
Clin Exp Dermatol 1995 Nov;20(6):502-3
Altomare GF, Capella GL, Frigerio E
Instituto di Dermatologia, Ospedale Maggiore IRCCS, Universita degli Studi di
Milano, Italy.
Erythema annulare centrifugum (EAC), a disease belonging to the poorly
characterized category of 'figurate erythemas', has been associated with a
variety of conditions, such as connective tissue diseases, infections, neoplasms
and drug reactions. Here we report a case of EAC associated with sarcoidosis,
the first case in the literature to our knowledge. EAC was the sole sign of the
granulomatous disease process, which was diagnosed by means of appropriate
investigations only after the patient reported the sudden resolution of a long-standing
sensitization to perfumes and parabens. Steroid treatment for sarcoidosis
improved the patient's condition, and restored the allergic response to these
substances.
============================================================
39.) [Recurrent annular erythema--cutaneous manifestation of Sjogren syndrome
with anti SS-A (Ro) and anti SS-B (La) antibodies].
============================================================
Nippon Rinsho 1995 Oct;53(10):2557-62
[Article in Japanese]
Usuda T
Division of Dermatology, Social Insurance Chukyo Hospital.
Eight cases of Sjogren syndrome (SjS) with anti-SS-A and anti-SS-B antibodies
are reported. They developed erythema annulare centrifugum-like annular erythema
which mainly appeared on the face. Laboratory tests showed similar serologic
changes. RA factor, speckled type antinuclear antibody, anti SS-A & SS-B
antibodies (DID & ELISA) were observed but complements and anti-double stranded
DNA antibodies were not detected. In spite of mild sicca symptoms, sialogram,
lip biopsy, Shirmer test and Rose Bengal staining showed typical changes of SjS.
It is considered that the recurrent annular erythema is a specific skin
manifestation of SjS with anti SS-A/SS-B antibodies.
============================================================
40.) Non-small-cell lung cancer with multiple paraneoplastic syndromes.
============================================================
Eur Respir J 1995 Jul;8(7):1231-4
Monsieur I, Meysman M, Noppen M, de Greve J, Delhove O, Velckeniers B,
Jacobvitz D, Vincken W
Dept of Internal Medicine, Academic Hospital, University of Brussels (AZ-VUB),
Belgium.
We describe the case of a patient with multiple paraneoplastic syndromes, six
in total, associated with a non-small-cell cancer of the lung. In this single
patient we found hypertrophic pulmonary osteoarthropathy, hyperkeratosis of
palms and soles, erythema annulare centrifugum, syndrome of inappropriate
secretion of antidiuretic hormone (SIADH), and ectopic andrenocorticotrophic
hormone (ACTH) and calcitonin production.
============================================================
41.) [Darier's erythema annulare centrifugum of neonatal onset with a 15 years'
follow-up. Efficacy of interferon and role of cytokines].
============================================================
Ann Dermatol Venereol 1995;122(6-7):422-6
[Article in French]
Guillet MH, Dorval JC, Larregue M, Guillet G
Service de Dermatologie, CHU Brest
INTRODUCTION. Darier's erythema annulare centrifugum (EAC) is a disease of
unknown etiology. Some observations of EAC in infancy suggest a better prognosis
for early EA. The observations presented herein gives different information
regarding prognosis and pathogenesis. OBSERVATION. A child presents with typical
lesions of EAC from early infancy up to the age of 15 years. Laboratory data are
normal. Similar lesions were locally reproduced by intradermal injection by
candidine but antifungal drugs were unsuccessful. Many antiinflammatory
treatments failed to improve the disease. Because of the improvement during
hyperthermic episodes, a treatment by subcutaneous interferon alpha (2 millions
U 3 times a week) was given for six months with a dramatic success (with seric
increase of TNF alpha and IL2) DISCUSSION. The long term duration of EAC
suggests that EA of infancy may represent the early beginning of Darier's EAC.
The efficacy of interferon suggests that cytokines are involved in the
pathogenesis of EAC.
============================================================
42.) Erythema annulare centrifugum unresponsive to immunosuppressive therapy.
============================================================
Br J Dermatol 1994 Oct;131(4):587
Phillips WG, Ramsay ID, Breathnach SM
Publication Types:
Letter
============================================================
============================================================
43.) Annular vasculitis associated with pregnancy.
============================================================
Br J Dermatol 1993 Nov;129(5):599-601
Kelly RI, Cook MG, Marsden RA
Department of Dermatology, St George's Hospital, London, U.K.
A 29-year-old woman presented in the 31st week of pregnancy with an unusual
bilateral, erythematous eruption on the posterior calves, which clinically
resembled erythema annulare centrifugum. A biopsy showed features of a mild
leucocytoclastic vasculitis. Within 2 days of delivery the rash had almost
resolved, suggesting that its activity was related to the pregnancy. The
diagnosis is consistent with 'annular vasculitis', which we suggest represents a
distinct variant of leucocytoclastic vasculitis, and a distinct
clinicopathological entity. We are not aware of any previous reports of an
association between annular vasculitis and pregnancy.
============================================================
44.) Inflammatory carcinoma masquerading as erythema annulare centrifugum.
============================================================
Acta Derm Venereol 1993 Apr;73(2):138-40
Reichel M, Wheeland RG
Department of Dermatology, University of California, Davis, Sacramento 95816.
A case of inflammatory carcinoma, or carcinoma erysipelatodes, clinically
resembling erythema annulare centrifugum is reported. The cutaneous inflammatory
carcinoma was due to metastasis by a signet-ring cell adenocarcinoma, probably
of gastrointestinal origin. This is the third reported case of inflammatory
carcinoma with signet-ring cell infiltration. Cancer patients with atypical or
unusual inflammatory dermatoses should be evaluated by skin biopsy because of
the possible association with the internal neoplastic process.
============================================================
45.) [Darier's erythema annulare centrifugum and primary Vaquez polycythemia]
============================================================
SO - Ann Dermatol Venereol 1984;111(8):767-8
AU - Triller R; Renard T; de Lacharriere O; Leonard F; Caulet T; Kalis B
PT - JOURNAL ARTICLE
============================================================
============================================================
46.) Recurrent annular erythema with anti-SSA/Ro and anti-SSB/La antibodies
localized on palms and fingers in an elderly man.
============================================================
SO - Lupus 1994 Feb;3(1):65-7
AU - Satoh M; Ajmani AK; Yamagata H; Okubo K; Akizuki M
PT - JOURNAL ARTICLE
AB - A 69-year-old Japanese man with recurrent annular erythema localized on
palms and flexor surface of fingers with anti-SSA/Ro and anti-SSB/La antibodies,
is reported. The present case indicates that even in an elderly man with
atypical localization, annular erythema with autoimmunity may be considered and
serological analysis should be performed. Systematic studies will be required to
understand the relationship between 'recurrent annular erythema associated with
anti-SSB/La antibodies' in Japanese, subacute cutaneous lupus erythematosus (SCLE)
and 'annular erythema associated with Sjogren's syndrome'.
============================================================
47.) Clinical and immunological analysis of annular erythema associated with
Sjogren syndrome.
============================================================
SO - Dermatology 1994;189 Suppl 1:14-7
AU - Katayama I; Yamamoto T; Otoyama K; Matsunaga T; Nishioka K
PT - JOURNAL ARTICLE
AB - Clinical and immunopathological analysis was performed on 24 cases of
Sjogren syndrome with annular erythema (AESjS). AESjS predominantly appears on
the cheek of the face where skin temperature is relatively low in comparison
with other sites. VCAM-1 and ICAM-1 were strongly expressed on endothelial cells
of AESjS, while epidermal expression of ICAM-1 was focal and weak. VCAM-1 mRNA
expression was also much more intense compared to systemic lupus erythematosus.
The lymphocyte response to staphylococcal enterotoxin B was higher in AESjS than
that of controls, and cells positive for T cell receptor V beta 6,9,12 were
expanded after the culture. Superantigen-driven endothelial-cell-dependent T
cell infiltration to the skin plays a crucial role in AESjS.
============================================================
48.) Clinical, serological and immunogenetic features of Japanese
anti-Ro/SS-A-positive patients with annular erythema.
============================================================
SO - Dermatology 1994;189 Suppl 1:11-3
AU - Miyagawa S
PT - JOURNAL ARTICLE
AB - Sixteen anti-Ro/SS-A-positive patients with recurrent annular erythema,
which has recently been recognized as a unique cutaneous manifestation of
Sjogren's syndrome, were studied. Eight of the 16 patients met the American
Rheumatism Association criteria for systemic lupus erythematosus. Fifteen
patients had anti-La/SS-B antibodies. Antibodies against U1RNP were detected in
2 patients with systemic lupus erythematosus, 1 with anti-Sm antibodies.
Patterns of autoimmune response to Ro/SS-A antigens were variable by immunoblot
analysis. HLA typing by the standard complement-dependent microcytotoxicity
assay revealed that all the 16 patients were positive for HLA-DRw52 antigens but
negative for either HLA-B8 or HLA-DR3 which is reportedly associated with the
autoimmune response to Ro/SS-A antigens in white and black patients.
============================================================
49.) Persistent annular erythema of infancy.
============================================================
SO - Pediatr Dermatol 1993 Mar;10(1):46-8
AU - Helm TN; Bass J; Chang LW; Bergfeld WF
PT - JOURNAL ARTICLE
AB - Annular erythema of infancy is an uncommon, nonpruritic, figurate
erythema that begins in the first year of life. Biopsy specimens reveal a
perivascular and interstitial lymphocytic infiltrate with numerous eosinophils.
The cause of the disorder is unknown, but a hypersensitivity response to
unrecognized antigens is suspected. The disorder is self-limited, but may last
for many months. In our patient the eruption continued 19 months after its onset.
============================================================
50.) HLA antigens in anti-Ro(SS-A)-positive patients with recurrent annular
erythema.
============================================================
SO - J Am Acad Dermatol 1993 Feb;28(2 Pt 1):185-8
AU - Miyagawa S; Dohi K; Shima H; Shirai T
PT - JOURNAL ARTICLE
AB - BACKGROUND: Recurrent annular erythema associated with the anti-Ro(SS-A)
antibody response has recently been reported in Orientals. The association is
assumed to represent a distinct clinical entity. OBJECTIVE: Our purpose was to
extend knowledge on the immunogenetic spectrum of the disease. METHODS: Sixteen
anti-Ro(SS-A)-positive Japanese patients with recurrent annular erythema and
Sjogren's syndrome were studied. The standard complement-dependent
microcytotoxicity assay was used to type the HLA-A, -B, -C, -DR, and -DQ, as
well as the HLA-DRw52 and -DRw53 antigens. RESULTS: All 16 patients were
positive for HLA-DRw52 antigens as compared with 52% of control subjects (p 0.01
relative risk 14.8). No significant deviations were noted in the phenotype
frequencies for HLA-A, -B, -C, and -DQ antigens. CONCLUSION: HLA-DRw52 is
closely related to annular erythema in anti-Ro(SS-A)-positive Japanese patients
with Sjogren's syndrome.
============================================================
51.) Urticated annular erythema: a new manifestation of Sjogren's syndrome.
============================================================
SO - Clin Exp Dermatol 1993 Jan;18(1):50-1
AU - Ostlere LS; Harris D; Rustin MH
PT - JOURNAL ARTICLE
AB - A patient with a unique urticated annular erythema associated with
Sjogren's syndrome and some features of systemic lupus erythematosus (SLE) is
reported. There has been one previous report of a similar eruption occurring in
a patient with Sjogren's syndrome.
============================================================
52.) Recurrent annular erythema associated with
anti-SS-============================================================
B/La antibodies: analysis of the disease-specific epitope.
SO - Br J Dermatol 1992 Dec;127(6):608-13
AU - Hoshino Y; Hashimoto T; Mimori T; Akizuki M; Nishikawa T
PT - JOURNAL ARTICLE
AB - We have found that anti-SS-B/La antibodies are present in a group of
patients with a characteristic recurrent annular erythema, and immunological
abnormalities. The presence of a disease-specific epitope for this entity has
been examined by comparing immunological reactivity of anti-SS-B/La antibodies
between these patients and patients with classical Sjogren's syndrome who have
anti-SS-B/La antibodies but do not have this characteristic erythema. In
immunoblotting using three different antigen sources, all the sera from both
groups exhibited the same reaction patterns. V8 protease mapping showed that the
sera could be divided into three groups by the difference in reactivity to two
main digested peptide fragments. However, no significant relationship of the
reactivity in peptide mapping between the two patient groups was observed.
Further studies are necessary to elucidate the role of anti-SS-B/La antibodies
in disease pathogenesis in these patients, in particular by more precise peptide
mapping using recombinant SS-B/La antigen proteins.
============================================================
53.) Erythema annulare centrifugum associated with gold sodium thiomalate
therapy.
============================================================
SO - J Am Acad Dermatol 1992 Aug;27(2 Pt 2):284-7
AU - Tsuji T; Nishimura M; Kimura S
PT - JOURNAL ARTICLE
AB - Two women with rheumatoid arthritis developed erythema annulare
centrifugum while receiving gold thiomalate therapy. Both patients had similar
clinical and histologic findings. Results of a lymphocyte stimulation test were
positive in one patient but not in the other.
============================================================
54.) Annular erythema. A comparative study of Sjogren syndrome with subacute
cutaneous lupus erythematosus.
============================================================
SO - Int J Dermatol 1991 Sep;30(9):635-9
AU - Katayama I; Teramoto N; Arai H; Nishioka K; Nishiyama S
PT - JOURNAL ARTICLE
AB - Annular erythema developed in 22 patients with Sjogren syndrome.
Clinically, the annular erythema was subdivided into three forms: Sweet
disease-like annular erythema with an elevated border (14 cases); subacute
cutaneous lupus erythematosus (SCLE)-like marginally scaled erythema (5 cases);
and papular erythema (3 cases). Histopathologically, features commonly seen in
annular erythema are deep perivascular and/or periappendageal infiltration of
the lymphocytes with an admixture of neutrophils or plasma cells and less
frequent epidermal changes suggestive of cutaneous lupus erythematosus.
Immunoglobulin or complement deposition along the dermoepidermal junction of
lesional skin was observed in 8 of 18 cases, and most of the dermal infiltrates
consisted of CD4(+), 4B4(+) cells. The appearance of anti-SS-A(Ro) (100%) and
anti-SS-B(La) (77%) was significantly higher in patients with annular erythema.
These results suggest that patients with Sjogren syndrome might have a distinct
annular erythematous lesion that is both clinically and histopathologically
different from SCLE, although close immunologic abnormalities exist in these two
diseases.
============================================================
55.) Annular erythema associated with Sjogren's syndrome: a variant of
systemic lupus erythematosus [see comments]
============================================================
SO - J Am Acad Dermatol 1991 Sep;25(3):557-60
AU - Ruzicka T; Faes J; Bergner T; Peter RU; Braun-Falco O
PT - COMMENT; JOURNAL ARTICLE
AB - We present a Burmese patient with widespread annular erythema associated
with Sjogren's syndrome. Unlike previously described cases, the disease occurred
in the setting of systemic lupus erythematosus. Photoprovocation testing
revealed light sensitivity in the UVA range with elicitation of subacute
cutaneous lupus erythematosus-like lesions. The presence of an erythema annulare
centrifugum-like eruption should initiate the search for Sjogren's syndrome and
systemic lupus erythematosus.
============================================================
56.) Lymphocyte response to staphylococcal enterotoxin B in patients with
annular erythema associated with Sjogren syndrome.
============================================================
SO - J Dermatol 1991 Feb;18(2):63-8
AU - Katayama I; Asai T; Nishiyama S; Nishioka K
PT - JOURNAL ARTICLE
AB - Lymphocyte response to staphylococcal enterotoxin B (SEB) was analysed in
11 cases with Sjogren syndrome (SjS) who developed annular erythema during the
course. Increased lymphocyte response against SEB was observed on day 5 in those
patients who developed annular erythema at the time of examination. A similar
reaction pattern was observed when Con A and PWM, but not protein A, were used
as the mitogen. No significant lymphocyte response was observed in the patients
in the inactive stage without annular erythema or in normal controls.
Furthermore, peripheral blood lymphocytes express LFA-1 after SEB stimulation.
These results suggest that lymphocytes from SjS patients react to various types
of antigenic or mitogenic stimulation and that they express cell adhesion
molecules, especially in patients with active annular erythema.
============================================================
57.) ICAM-1 and LFA-1 expressions in the lesional skin of annular erythema
associated with Sjogren syndrome.
============================================================
SO - J Dermatol 1990 Dec;17(12):719-23
AU - Katayama I; Asai T; Nishiyama S; Nishioka K
PT - JOURNAL ARTICLE
AB - ICAM-1 and LFA-1 expression was studied in the lesional skin of ten cases
of annular erythema associated with Sjogren syndrome. Most of the infiltrating
mononuclear cells around blood vessels expressed LFA-1 in addition to its strong
expression on vascular endothelial cells and focal expression on the epidermal
basal cell layer in 3 cases. ICAM-1 expression on vascular endothelial cells was
similar to LFA-1, although relatively focal and weak expression was observed on
mononuclear cells. ICAM-1 expression on keratinocytes was focal and limited to
the basal cell layer in annular erythema. These findings suggest that strong
expression of ICAM-1 on endothelial cells but not keratinocytes and LFA-1 on
mononuclear cells might play some role in the induction of skin lesions in
annular erythema associated with Sjogren syndrome.
============================================================
58.) Annular erythema associated with primary Sjogren syndrome: analysis of T
cell subsets in cutaneous infiltrates [see comments]
============================================================
SO - J Am Acad Dermatol 1989 Dec;21(6):1218-21
AU - Katayama I; Asai T; Nishioka K; Nishiyama S
PT - JOURNAL ARTICLE
AB - Immunohistochemical analysis was performed on the annular erythema
associated with Sjogren syndrome. This type of annular erythema is characterized
by a doughnutlike appearance with an elevated border and central pallor; it is
distinct from subacute cutaneous lupus erythematosus. Histologically this
erythema is characterized by coat sleeve-like infiltration of lymphocytes around
blood vessels and by nuclear debris in the connective tissue. Vasculitis or
epidermal changes suggestive of lupus erythematosus were not observed in any of
the cases, although immunoglobulin or complement deposition along the basement
membrane zone and focal liquefaction degeneration of the basal layer in involved
skin were seen in some cases. Major dermal infiltrates consisted primarily of
CD4+ and 4B4+ lymphocytes.
============================================================
59.) Annular erythema in identical twins.
============================================================
SO - Cutis 1989 Aug;44(2):139-40
AU - Watsky KL; Hansen T
PT - JOURNAL ARTICLE
AB - A case of superficial gyrate erythema that was indistinguishable from
erythema annulare centrifugum occurred in identical twins. We propose to include
a familial cause among the known causes of erythema annulare centrifugum rather
than considering this a separate entity, "familial annular erythema."
============================================================
60.) Annular erythema: a possible association with primary Sjogren's syndrome.
============================================================
SO - J Am Acad Dermatol 1989 Apr;20(4):596-601
AU - Teramoto N; Katayama I; Arai H; Eto H; Kamimura K; Uetsuka M; Kondo S;
Nishioka K; Nishiyama S
PT - JOURNAL ARTICLE
AB - In four patients with primary Sjogren's syndrome a distinct annular
erythema developed, which was characterized by a wide, elevated border (which
can be likened to a doughnut ring) and central pallor. Histologically, there was
a coat sleeve-like infiltration of lymphocytes around blood vessels and nuclear
debris in the connective tissue. Vasculitis or epidermal changes suggestive of
lupus erythematosus were not observed, and there was no immunoglobulin
deposition along the basement membrane zone. This annular erythema may be a
cutaneous manifestation of Sjogren's syndrome.
============================================================
61.) Neonatal lupus syndrome and microtubular structure.
============================================================
SO - J Dermatol 1989 Feb;16(1):54-8
AU - Nitta Y; Ohashi M
PT - JOURNAL ARTICLE
AB - A female infant, at 6 weeks old, with the clinical manifestation of
annular erythemas on the trunk and face, was positive for anti-SS-A and
anti-SS-B antibodies. The annular erythema disappeared spontaneously at the age
of 7 months when anti-SS-A and anti-SS-B antibodies were negative. Electron
microscopic observation of the vascular endothelial cells on the annular
erythema revealed microtubular structures. Later microtubular structures were
found absent from the vascular endothelial cells of the area where the annular
erythema had disappeared. The patient's mother is suffering from Sjogren's
syndrome; she has no clinical symptoms but anti-SS-A and anti-SS-B antibodies
are positive and a biopsy of small salivary glands of the lip demonstrated a
marked periductal mononuclear cell infiltration. Microtubular structures were
observed in her vascular endothelial cells in the small salivary gland region.
These findings suggest that disappearance of microtubular structure may have
some relationship with anti-SS-A and anti-SS-B antibodies.
============================================================
62.) Erythema annulare of infancy.
============================================================
SO - Cutis 1988 Oct;42(4):353-5
AU - Metzker A; Frumkin A
PT - JOURNAL ARTICLE
AB - A case of erythema annulare of infancy lasting for two years is presented.
The striking features of this overall annular eruption, of idiopathic origin,
are noted. This case is unusual because of the late onset and the long duration
of symptoms. Such cases warrant prolonged follow-up examinations after the
annular lesions disappear.
============================================================
63.) An annular erythema of infancy.
============================================================
SO - Arch Dermatol 1987 Apr;123(4):510-3
AU - Cox NH; McQueen A; Evans TJ; Morley WN
PT - JOURNAL ARTICLE
AB - An unusual annular and arciform erythema in an infant is reported. Skin
lesions appeared when the child was 4 days old, and multiple lesions have been
present during the subsequent two years. Individual lesions gradually enlarge
over a period of a few weeks, and they resolve spontaneously without any
residual cutaneous abnormality. This annular erythema is clinically and
histologically distinct from previously described annular erythemas of infancy,
with which it is compared.
============================================================
64.)Reactive annular erythema after intramuscular vitamin K.
============================================================
SO - Cutis 1986 Jun;37(6):445-8
AU - Kay MH; Duvic M
PT - JOURNAL ARTICLE
AB - We present a case of a 70-year-old woman who received multiple
intramuscular vitamin K injections before undergoing an invasive diagnostic
procedure. Four weeks later she noted enlarging annular erythematous plaques at
the sites of each injection. Although this occurrence has been recognized in the
European literature, it either occurs less frequently in the United States or is
not commonly reported. This is the second case report in the English literature.
============================================================
65.) Annular erythema of infancy.
============================================================
SO - J Am Acad Dermatol 1986 Feb;14(2 Pt 2):339-43
AU - Hebert AA; Esterly NB
PT - JOURNAL ARTICLE
AB - An urticarial annular erythema began in our patient at 6 weeks of age and
resolved completely by 14 months of age. Individual lesions lasted 2 to several
days and tended to erupt in cycles, with each cycle lasting 5 to 6 weeks. The
lesions were totally asymptomatic and left no residual scaling or
hyperpigmentation. Histologically, a dense perivascular infiltrate of
lymphocytes, histiocytes, eosinophils, and a few plasma cells was evident. The
clinical appearance, course, and histologic characteristics resemble closely the
case reported by Peterson and Jarratt in 1981.
============================================================
66.) [Erythema annulare centrifugum revealing linear IgA dermatitis of
childhood]
============================================================
SO - Ann Dermatol Venereol 1986;113(12):1213-22
AU - Larregue M; Bressieux JM; Laidet B; Cavaroc Y; Gallet P; de Giacomoni P;
Touchard G
PT - JOURNAL ARTICLE
AB - Linear IgA dermatitis was diagnosed in a 13-year old girl with erythema
annulare centrifugum (EAC) on the basis of the criteria laid down by Jablonska:
vesiculo-bullous eruption with specific patterns on subsequent flare-ups,
subepidermal vesicles and bullae with papillary eosinophilic abscesses in
erythematous areas, positive linear IgA antibody response at direct
immunofluorescence in the lamina basal, absence of intolerance to gluten and
responsiveness to sulfapyridine and dapsone. This patient was followed up for 10
years. During the first 5 years any attempt at withdrawing dapsone resulted in
quick relapse which always remained responsive to that drug. After 5 years
discontinuing dapsone was no longer followed by relapse, and the girl was
considered clinically cured. Yet direct immunofluorescence in healthy skin
remained positive for 2 years after treatment was stopped, as has previously
been reported. At the age of 23, after 5 years without treatment the patient
remained cured. This case demonstrates that linear IgA dermatitis is one of the
causes of EAC. Autoimmune bullous diseases, such as pemphigus with eosinophilic
spongiosis, bullous pemphigoid and dermatitis herpetiformis, are known to
present as EAC. Direct cutaneous immunofluorescence is necessary to the
aetiological diagnosis of EAC.
============================================================
67.) Erythema annulare centrifugum: an unusual case due to hydroxychloroquine
sulfate.
============================================================
SO - Cutis 1985 Aug;36(2):129-30
AU - Hudson LD
PT - JOURNAL ARTICLE
AB - Erythema annulare centrifugum presents as a cutaneous hypersensitivity to
diverse causes including fungal and yeast infections, parasitic infestations,
drugs, and, rarely, occult malignancies. A prolonged case of erythema annulare
centrifugum secondary to the use of hydroxychloroquine sulfate is presented. The
prolonged time needed for clearing after discontinuation of the medication is
thought to result from the melanocyte-binding characteristics of the drug.
============================================================
68.) 'Persistent' annular erythema of infancy.
============================================================
SO - Arch Dermatol 1984 Aug;120(8):1069-72
AU - Toonstra J; de Wit RF
PT - JOURNAL ARTICLE
AB - An unusual annular erythema occurred in a 6-month-old girl. Recurrent
annular lesions appeared on the face and back, but annular lesions persisted for
ten months on the distal extremities. Eleven months after the eruption appeared,
it resolved completely without recurrence. This seemingly unique condition is
compared with other cases of chronic annular erythemas, especially those
previously described as erythema gyratum perstans.
============================================================
69.) Erythema annulare centrifugum associated with ascariasis.
============================================================
SO - Arch Dermatol 1981 Sep;117(9):582-5
AU - Hendricks AA; Lu C; Elfenbein GJ; Hussain R
PT - JOURNAL ARTICLE
AB - Erythema annulare centrifugum (EAC) is a figurate erythema that has been
associated with man diverse entities. A case of EAC was related to infestation
by the nematode, Ascaris lumbricoides. A careful examination of the patient did
not define an immunologic basis for EAC. Results of lymphocyte stimulation tests
of the patient showed an immune response to A lumbricoides extracts but not to A
suum extracts. This finding is of practical importance, since most laboratoires
use A suum extracts in routine skin and serologic tests for human ascariasis.
============================================================
70.) Annular erythema of infancy.
============================================================
SO - Arch Dermatol 1981 Mar;117(3):145-8
AU - Peterson AO Jr; Jarratt M
PT - JOURNAL ARTICLE
AB - The lesions of an unusual annular erythema in an infant evolved from
erythematous papules, to rings, to interrupted arcs over 36 to 48 hours, and
then resolved without a trace. New lesions appeared and evolved with remarkable
uniformity for eight months and then disappeared. This seemingly unique eruption
is compared with other annular erythemas described in infants.
============================================================
71.) Annular erythema as an unusual manifestation of chronic disseminated
lupus erythematosus.
============================================================
SO - Arch Dermatol 1980 Apr;116(4):450-3
AU - Maciejewski W
PT - JOURNAL ARTICLE
AB - Numerous annular erythematous lesions developed in a 47-year-old woman,
involving most of the integument. Thorough clinical, histopathologic, and
immunopathologic investigations confirmed the diagnosis of lupus erythematosus.
Unusual clinical, histologic, and immunofluorescence microscopy patterns emerged
during the course of the disease, which was resistant to treatment.
============================================================
72.) Multiple annular erythema [letter]
============================================================
SO - J Dermatol 1994 Sep;21(9):699-700
AU - Miyoshi H; Kanzaki T
PT - LETTER
============================================================
============================================================
73.) Reactive erythemas: erythema annulare centrifugum and erythema gyratum
repens.
============================================================
SO - Clin Dermatol 1993 Jan-Mar;11(1):135-9
AU - Tyring SK
PT - JOURNAL ARTICLE; REVIEW (57 references); REVIEW, TUTORIAL
============================================================
============================================================
74.) [Squamous erythema annulare centrifugum]
============================================================
SO - Ann Dermatol Venereol 1993;120(3):237-40
AU - Petit A; Nahmias M; Gaulier A; Sigal-Nahum M; Ruzniewsky P; Belaich S
PT - JOURNAL ARTICLE
AB - A case of squamous erythema annulare centrifugum has been observed. It
was characterized by striking clinical features and peculiar histological
findings, including necrosis of keratinocytes. A search for causative factors
was negative. Treatment with tar ointment (Brocq) rapidly resulted in dramatic
healing of the lesions; however, the usual features of annular psoriasis were
absent in our case.
============================================================
75.) Annular erythema associated with Sjogren's syndrome [letter; comment]
============================================================
SO - J Am Acad Dermatol 1992 Aug;27(2 Pt 1):276
AU - Katayama I; Teramoto N; Arai H; Nishiyama S; Nishioka K
PT - COMMENT; LETTER
============================================================
============================================================
76.) An intensive care unit nurse with a recurring annular lesion. Erythema
annulare centrifugum (EAC).
============================================================
SO - Arch Dermatol 1992 Jul;128(7):977, 980
AU - Janss G; Schmidt K; Gattuso P; Massa M; Welykyj S
PT - JOURNAL ARTICLE
============================================================
============================================================
77.) Erythema annular centrifugum in Q fever.
============================================================
SO - Int J Dermatol 1991 Jul;30(7):502
AU - Betlloch I; Amador C; Chiner E; Varona C; Carbonell C; Vilar A
PT - JOURNAL ARTICLE
============================================================
============================================================
78.) Erythema annulare centrifugum caused by hydrochlorothiazide-induced
interstitial nephritis.
============================================================
SO - Int J Dermatol 1988 Mar;27(2):129-30
AU - Goette DK; Beatrice E
PT - JOURNAL ARTICLE
============================================================
============================================================
79.) [Erythema annulare centrifugum disclosing hyperthyroidism]
============================================================
SO - Ann Dermatol Venereol 1988;115(6-7):721-3
AU - Launay P; Blanc D; Paris B; Quencez E; Drobacheff C; Zultak M
PT - JOURNAL ARTICLE
============================================================
============================================================
80.) Eruption resembling erythema annulare centrifugum due to thiacetazone [letter]
============================================================
SO - Australas J Dermatol 1987 Apr;28(1):44
AU - Ramesh V
PT - LETTER
============================================================
============================================================
81.) [Erythema annulare centrifugum caused by aldactone]
============================================================
SO - Ann Dermatol Venereol 1987;114(3):375-6
AU - Carsuzaa F; Pierre C; Dubegny M
PT - JOURNAL ARTICLE
============================================================
============================================================
82.) [On the physiopathology of erythema annulare centrifugum]
============================================================
SO - Ann Dermatol Venereol 1987;114(5):709-15
AU - Litoux P
PT - JOURNAL ARTICLE; REVIEW (22 references)
============================================================
============================================================
83.) Erythema annulare centrifugum associated with liver disease.
============================================================
SO - Arch Dermatol 1986 Nov;122(11):1239-40
AU - Tsuji T; Kadoya A
PT - JOURNAL ARTICLE
============================================================
============================================================
84.) [Erythema annulare centrifugum and Hashimoto's thyroiditis]
============================================================
SO - Ann Dermatol Venereol 1986;113(11):1087-8
AU - Thess F; Rigon JL; Cuny JF; Schmutz JL; Weber M; Beurey J
PT - JOURNAL ARTICLE
============================================================
============================================================
85.) Erythema annulare centrifugum associated with piroxicam [letter]
============================================================
SO - J Am Acad Dermatol 1985 Nov;13(5 Pt 1):840-1
AU - Hogan DJ; Blocka KL
PT - LETTER
============================================================
============================================================
86.) Annular erythema with histologic features of leukocytoclastic vasculitis
in ulcerative colitis.
============================================================
SO - Cutis 1985 Mar;35(3):250-2
AU - Aram H; Rubinstein N; Granot E
PT - JOURNAL ARTICLE
============================================================
87.) Erythema annulare centrifugum and malignant histiocytosis--report of a
case.
============================================================
SO - Clin Exp Dermatol 1984 Nov;9(6):608-13
AU - Dodd HJ; Kirby JD; Chambers TJ; Stansfeld AG
PT - JOURNAL ARTICLE
============================================================
============================================================
88.) Pityrosporum infection in an infant with lesions resembling erythema
annulare centrifugum.
============================================================
SO - Arch Dermatol 1984 Mar;120(3):380-2
AU - Kikuchi I; Ogata K; Inoue S
PT - JOURNAL ARTICLE
AB - Erythematous, scaling patches over the face, torso, and extremities
developed in a 2-month-old female infant. The facial lesions enlarged and became
confluent, while the torso and leg lesions enlarged and assumed an annular
configuration. Spores of Pityrosporum ovale and Pityrosporum orbiculare were
found in large numbers in potassium hydroxide preparations from these lesions, a
finding confirmed by culture. Clotrimazole ointment was applied, and the lesions
resolved within one week, leaving depigmentation. The findings in this case and
those of erythema gyratum atrophicans transiens neonatale resembled each other
except for the demonstration of Pityrosporum spores. We assume that the disorder
in our patient may represent superficial gyrate erythema (erythema annulare
centrifugum) induced by Pityrosporum spores.
============================================================
89.) Erythema annulare centrifugum: a review of 24 cases with special
reference to its association with underlying disease.
============================================================
SO - Clin Exp Dermatol 1983 Jul;8(4):383-7
AU - Mahood JM
PT - JOURNAL ARTICLE
============================================================
============================================================
90.) [Pemphigoid with recurrence of the centrifugal-development bullous
annular erythema type]
============================================================
SO - Ann Dermatol Venereol 1983;110(12):1021-2
AU - Jeanmougin M; Lemarchand-Venencie F; Ribrioux A; Bardy-Decrion I; Civatte
J
PT - JOURNAL ARTICLE
============================================================
============================================================
91.) [Bullous pemphigoid with an erythema annulare centrifugum appearance and
a bullous border]
============================================================
SO - Ann Dermatol Venereol 1983;110(12):1017-8
AU - Chouvet B; Barthelemy H; Forestier JY; Hermier C; Thivolet J
PT - JOURNAL ARTICLE
============================================================
============================================================
92.) [Erythema annulare centrifugum and antinuclear antibodies]
============================================================
SO - Ann Dermatol Venereol 1983;110(9):711-2
AU - Elnekave FL; Puissant A; Morel P; Noury-Duperrat G; Beltzer-Garelly E
PT - JOURNAL ARTICLE
============================================================
============================================================
93.) Erythema annulare centrifugum. A case due to tuberculosis.
============================================================
SO - Int J Dermatol 1982 Nov;21(9):538-9
AU - Burkhart CG
PT - JOURNAL ARTICLE
============================================================
============================================================
94.) Erythema annulare centrifugum and Graves' disease [letter]
============================================================
SO - Arch Dermatol 1982 Sep;118(9):623
AU - Braunstein BL
PT - LETTER
============================================================
============================================================
95.) Cimetidine-induced erythema annulare centrifugum: no cross-sensitivity
with ranitidine.
============================================================
SO - Br Med J (Clin Res Ed) 1981 Sep 12;283(6293):698
AU - Merrett AC; Marks R; Dudley FJ
PT - JOURNAL ARTICLE
============================================================
============================================================
96.) [Nosologic problems posed by a case of desquamative erythema annulare
centrifugum]].
============================================================
Bull Soc Fr Dermatol Syphiligr 1971;78(1):55
[Article in French]
Chasseuil M
============================================================
============================================================
97.) [Erythema annulare centrifugum Darier as a reaction form in diseases of
the reticulo-histiocyte system].
============================================================
Dermatol Wochenschr 1967 May 27;153(21):604-12
[Article in German]
Kimmig J, Rohde B, Janner M
============================================================
============================================================
98.) [Erythema annulare centrifugum of Darier, squamous variety].
============================================================
Bull Soc Fr Dermatol Syphiligr 1966 Jan-Feb;73(1):111-3
[Article in French]
Labouche F, Henaff R
============================================================
============================================================
99.) [Erythema annulare centrifugum with loco-regional recurrences during the
course of tuberculous coxitis. Focal reaction to tuberculin].
============================================================
Bull Soc Fr Dermatol Syphiligr 1965 May-Jun;72(3):259-62
[Article in French]
Coste F, Piguet B, Bontoux D
============================================================
100.) The Gyrate Erythemas
============================================================
seminars of dermatology 1984 Dec;3(4):327-336
Harry J. Hurley, MD, Jeffrey P.
============================================================
DATA-MEDICOS/DERMAGIC-EXPRESS No 3-(96) 27/01/2.001 DR. JOSE LAPENTA R.
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