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Researchers Discover A Gene That Regulates And Blocks Ovulation - Canadian And European Scientists Collaborate To Unlock Mysteries Of Lrh1 Gene

Researchers Discover A Gene That Regulates And Blocks Ovulation - Canadian And European Scientists Collaborate To Unlock Mysteries Of Lrh1 Gene How Lorazepam may help us. Low costed Lorazepam Unintended pregnancy FAQ

How Lorazepam may help us.

Lorazepam: uses

Lorazepam is used to treat anxiety. Lorazepam belongs to a class of drugs known as benzodiazepines which act on brain and nerves ( central nervous system ) to produce a calming effect. Lorazepam works by enhancing effects of a certain natural chemical in body ( GABA ) .

Lorazepam: how to use

Don't swallow whole. Place the tablet under tongue. It will dissolve in about 20 seconds. Wait at least 2 minutes before swallowing to make sure all drug is absorbed.

Dosage is based on your medical condition and response to therapy. If directed by your doctor, use Lorazepam regularly in order to get the most benefit from it. To help we remember, use it at the same time ( s ) each day.

Lorazepam may cause dependence, especially if it has been used regularly for an extended time ( more than 1-4 weeks ) , if it has been used in high doses, or if you have a history of alcoholism, drug abuse, or personality disorder. In such cases, if you suddenly stop Lorazepam, withdrawal reactions may occur while use Lorazepam. Such reactions can include seizures, trouble sleeping, mental/mood changes, increased reactions to noise/touch/light, nausea, vomiting, diarrhea, loss of appetite, stomach pain, hallucinations, numbness/tingling of arms and legs, muscle pain, fast heartbeat, short-term memory loss, and very high fever. Report any such reactions to your doctor immediately. When stopping extended, regular treatment with Lorazepam, gradually reducing the dosage as directed will help prevent withdrawal reactions. Consult your doctor or pharmacist for more details.

Though it's very unlikely to occur, Lorazepam can also result in abnormal drug-seeking behavior ( addiction/habit forming ) . Don't increase your dose, take it more frequently, or use it for a longer time than prescribed. Properly stop medication when so directed. This will lessen chances of becoming addicted.

Don't suddenly stop using Lorazepam without your doctor's approval. Some conditions may become worse when drug is abruptly stopped. Your dose may need to be gradually decreased.

When used for an extended time, Lorazepam mayn't work as well and may require different dosing. Talk with your doctor if this medication stops working well. Don't increase your dose without first talking to your doctor.

Inform your doctor if your condition persists or worsens.

Lorazepam: other used

This section contains uses of Lorazepam that aren't listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use Lorazepam for a condition that's listed in this section only if it has been so prescribed by your health care professional.

If directed by your doctor, Lorazepam may also be used to reduce symptoms of alcohol withdrawal, to prevent nausea and vomiting due to chemotherapy, and for sleeping trouble ( insomnia ) .

Lorazepam: side effects

Drowsiness, dizziness, loss of coordination, headache, nausea, blurred vision, change in sexual interest/ability, hair loss, constipation, heartburn, or change in appetite may occur while use Lorazepam. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed Lorazepam because he or she has judged that benefit to you is greater than the risk of side effects. Many people using Lorazepam do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

A very serious allergic reaction to Lorazepam is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include:

This isn't a complete list of possible side effects. If we notice other effects not listed above, contact your doctor or pharmacist.

Lorazepam: precautions

Before taking Lorazepam, tell your doctor or pharmacist if we are allergic to it; or to other benzodiazepines ( e. g. , diazepam, alprazolam, clonazepam ) ; or if we have any other allergies.

Lorazepam shouldn't be used if we have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if we have:

Before using Lorazepam, tell your doctor or pharmacist your medical history, especially of:

Lorazepam may make you dizzy or drowsy or cause blurred vision; use caution engaging in activities requiring alertness or clear vision such as driving or using machinery. Avoid alcoholic beverages.

Before having surgery, tell your doctor or dentist that we are using Lorazepam.

The elderly may be more sensitive to effects of this drug, especially drowsiness and unsteadiness. Also, the elderly mayn't experience relief of anxiety with Lorazepam. It may have opposite effect on elderly, causing mental/mood changes, sleeping problems, increase in sexual interest, or hallucinations.

Children mayn't experience relief of anxiety with Lorazepam. It may have opposite effect on children, causing agitation, shaking, or hallucinations.

Lorazepam isn't recommended for use during pregnancy. It may harm an unborn baby. Infants born to mothers who took this drug during last weeks before delivery have had withdrawal symptoms, including unusual drowsiness, slowed breathing, and feeding problems. Consult your doctor for more details

Lorazepam passes into breast milk and could have undesirable effects on a nursing infant. Breast-feeding is not recommended while using Lorazepam. Consult your doctor before breast-feeding.

Lorazepam: interactions

Your healthcare professionals ( e. g. , doctor or pharmacist ) may already be aware of any possible drug interactions and may be monitoring we for it. Do not start, stop or change dosage of any medicine before checking with them first.

Lorazepam shouldn't be used with following medication because a very serious interactions may occur while use Lorazepam:

If we are currently using Lorazepam listed above, tell your doctor or pharmacist before starting Lorazepam.

Before using Lorazepam, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

Tell your doctor or pharmacist if we also take drugs that cause drowsiness such as: certain antihistamines ( e. g. , diphenhydramine ) , anti-seizure drugs ( e. g. , carbamazepine ) , medicine for sleep or anxiety ( e. g. , alprazolam, diazepam, zolpidem ) , muscle relaxants, narcotic pain relievers ( e. g. , codeine ) , psychiatric medicines ( e. g. , chlorpromazine, risperidone, amitriptyline, trazodone ) .

Check labels on all your medicines ( e. g. , cough-and-cold products ) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.

This document does not contain all possible interactions. Therefore, before using Lorazepam, tell your doctor or pharmacist of all products we use. Keep a list of all your medications with you, and share list with your doctor and pharmacist.

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Researchers Discover A Gene That Regulates And Blocks Ovulation - Canadian And European Scientists Collaborate To Unlock Mysteries Of Lrh1 Gene

Researchers Discover A Gene That Regulates And Blocks Ovulation - Canadian And European Scientists Collaborate To Unlock Mysteries Of Lrh1 Gene How Lorazepam may help us. Low costed Lorazepam Unintended pregnancy FAQ

A group of Canadian and European researchers have unlocked mystery of a gene with potential to regulate and block ovulation. The new study - a collaboration between the Universite de Montreal in Canada and Institut de g�netique et biologie mol�culaire et cellulaire of Universit� de Louis Pasteur, Strasbourg, France - is published in the current issue of the journal Genes & Development .

" Our findings demonstrate that Lrh1 gene is essential in regulating ovulation, " said Bruce D. Murphy, director the Animal Research Centre at Faculty of Veterinary Medicine and an adjunct professor of and obstetrics and gynaecology at Faculty of Medicine of Universit� de Montr�al. " Until this point, role of Lrh1 in female fertility was unclear, but we've found the gene regulates multiple mechanisms of ovulation and may affect fertilization. "

To reach their conclusions, the research team developed a new type of genetically modified mouse whose Lrh1 gene was selectively blocked in the ovary. They found that deletion of Lrh1 gene effectively stopped ovulation. " This discovery means we can envision new contraceptives that selectively stop ovulation, " said Doctor Murphy. " If created, these new contraceptives would be more effective and produce less side-effects than current steroid-based forms of birth control. "

What is more, findings could lead to development of pharmaceuticals that activate the Lrh1 gene, which may prove critical in giving infertile couples hope in producing children. " This is an important development, since 15 percent of couples are infertile, " said Doctor Murphy. " The widespread role of this gene in the ovary indicates that it may be targeted to stimulate ovulation and, eventually, conception. "

Partners in research:

" Lrh1 regulates ovulation and fertility, " by Rajesha Duggavathi, Bruce D. Murphy, , David H. Volle, Chikage Mataki, Maria C. Antal, Nadia Messaddeq, Johan Auwerx and Kristina Schoonjans, was supported by the CIHR in Canada; CNRS, INSERM and Serono Foundation in Europe.

About Rajesha Duggavathi

Dr. Rajesha Duggavathi is a postdoctoral fellow at Universit� de Montreal who completed most of work in this study. He was supported by fellowships from NSERC and Serono Foundation.

About Bruce D. Murphy

Doctor Bruce D. Murphy is director of the Animal Reproduction Research Centre, one North America's largest hubs of its kind, which is based at the Universit� de Montr�al's Faculty of Veterinary Medicine in Saint-Hyacinthe. The Centre specializes in reproductive biology, embryo transplants and notably cloned a world famous Holstein calf named Starbuck II in 2000.

About Universit� de Montr�al's Faculty of Veterinary Medicine

Farm, domestic and wild animal health is a priority for the Universit� de Montr�al's Faculty of Veterinary Medicine. Since its 1886 foundation, North America's only French veterinary medical school has been a leader in the teaching, treatment and research in its field. The Faculty, based in Saint-Hyacinthe, features 120 professors, clinicians and researchers, 420 undergraduate and 200 graduate students, as well as 300 support staff. Thanks to its new University Veterinary Hospital Centre, Faculty provides both quality education and unique expertise for businesses, government agencies and general public. On web: http: //www. medvet. umontreal. ca.


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